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Literature summary extracted from
- The role of histone demethylase GASC1 in cancer and its therapeutic potential (2013), Curr. Cancer. Ther. Rev., 9, 78-85 .
No PubMed abstract available
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.11.66 | (R)-2-hydroxyglutarate | - |
Homo sapiens |  |
| 1.14.11.66 | (S)-2-hydroxyglutarate | - |
Homo sapiens | |
| 1.14.11.66 | 5-(anilinomethyl)quinolin-8-ol | - |
Homo sapiens | |
| 1.14.11.66 | caffeic acid | - |
Homo sapiens | |
| 1.14.11.66 | dimethyl 4-hydroxy-1H-pyrazole-3,5-dicarboxylate | - |
Homo sapiens | |
| 1.14.11.66 | methylstat | - |
Homo sapiens | |
| 1.14.11.66 | N-oxalylglycine | - |
Homo sapiens | |
| 1.14.11.66 | NCDM-32 | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.11.66 | [histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 | Homo sapiens | overall reaction | [histone H3]-N6-methyl-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2 | - |
? | |
| 1.14.11.66 | [histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2 | Homo sapiens | - |
[histone H3]-N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2 | - |
? | |
| 1.14.11.66 | [histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 | Homo sapiens | - |
[histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2 | - |
? | |
| 1.14.11.66 | [polycomb 2 protein]-N6,N6-dimethyl-L-lysine191 + 2-oxoglutarate + O2 | Homo sapiens | - |
[polycomb 2 protein]-N6-methyl-L-lysine191 + succinate + formaldehyde + CO2 | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.11.66 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.11.66 | breast cancer cell | - |
Homo sapiens | - |
| 1.14.11.66 | colorectal cancer cell | - |
Homo sapiens | - |
| 1.14.11.66 | esophageal squamous cell carcinoma cell | - |
Homo sapiens | - |
| 1.14.11.66 | glioma cell | - |
Homo sapiens | - |
| 1.14.11.66 | hepatoma cell | - |
Homo sapiens | - |
| 1.14.11.66 | lung cancer cell | - |
Homo sapiens | - |
| 1.14.11.66 | medulloblastoma cell | - |
Homo sapiens | - |
| 1.14.11.66 | ovary cancer cell | - |
Homo sapiens | - |
| 1.14.11.66 | prostate gland cancer cell | - |
Homo sapiens | - |
| 1.14.11.66 | renal cell carcinoma cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.11.66 | [histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 | overall reaction | Homo sapiens | [histone H3]-N6-methyl-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2 | - |
? | |
| 1.14.11.66 | [histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2 | - |
Homo sapiens | [histone H3]-N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2 | - |
? | |
| 1.14.11.66 | [histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 | - |
Homo sapiens | [histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2 | - |
? | |
| 1.14.11.66 | [polycomb 2 protein]-N6,N6-dimethyl-L-lysine191 + 2-oxoglutarate + O2 | - |
Homo sapiens | [polycomb 2 protein]-N6-methyl-L-lysine191 + succinate + formaldehyde + CO2 | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.11.66 | GASC1 | gene name, gene amplified in squamous cell carcinoma 1 | Homo sapiens |
| 1.14.11.66 | JMJD2C | - |
Homo sapiens |
| 1.14.11.66 | Kdm4c | - |
Homo sapiens |
| 1.14.11.66 | lysine-specific demethylase 4C | - |
Homo sapiens |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 1.14.11.66 | 0.001 | - |
pH and temperature not specified in the publication | Homo sapiens | NCDM-32 | |
| 1.14.11.66 | 0.0021 | - |
pH and temperature not specified in the publication | Homo sapiens | 5-(anilinomethyl)quinolin-8-ol | |
| 1.14.11.66 | 0.0034 | - |
pH and temperature not specified in the publication | Homo sapiens | methylstat | |
| 1.14.11.66 | 0.0137 | - |
pH and temperature not specified in the publication | Homo sapiens | caffeic acid | |
| 1.14.11.66 | 0.079 | - |
pH and temperature not specified in the publication | Homo sapiens | (R)-2-hydroxyglutarate | |
| 1.14.11.66 | 0.097 | - |
pH and temperature not specified in the publication | Homo sapiens | (S)-2-hydroxyglutarate | |
| 1.14.11.66 | 0.147 | - |
pH and temperature not specified in the publication | Homo sapiens | dimethyl 4-hydroxy-1H-pyrazole-3,5-dicarboxylate | |
| 1.14.11.66 | 0.5 | - |
pH and temperature not specified in the publication | Homo sapiens | N-oxalylglycine | |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.14.11.66 | physiological function | enzyme over-production may induce alterations in epigenetic histone methylation and affects the expression of key genes that are implicated in carcinogenesis and stem cell properties in human cancer | Homo sapiens |
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Release 2023.1 (January 2023)
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