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Literature summary extracted from

  • Heggermont, W.A.; Papageorgiou, A.P.; Quaegebeur, A.; Deckx, S.; Carai, P.; Verhesen, W.; Eelen, G.; Schoors, S.; van Leeuwen, R.; Alekseev, S.; Elzenaar, I.; Vinckier, S.; Pokreisz, P.; Walravens, A.S.; Gijsbers, R.; Van Den Haute, C.; Nickel, A.; Schroen, B.; van Bilsen, M.; Janssens, S.; Maack, C.; Pinto, Y.; Carmeliet, P.; Heymans, S.
    Inhibition of microRNA-146a and overexpression of its target dihydrolipoyl succinyltransferase protect against pressure overload-induced cardiac hypertrophy and dysfunction (2017), Circulation, 136, 747-761 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.61 succinyl-CoA + enzyme N6-(dihydrolipoyl)lysine Mus musculus
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CoA + enzyme N6-(S-succinyldihydrolipoyl)lysine
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.61 Mus musculus Q9D2G2
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.61 heart
-
Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.61 succinyl-CoA + enzyme N6-(dihydrolipoyl)lysine
-
Mus musculus CoA + enzyme N6-(S-succinyldihydrolipoyl)lysine
-
?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.61 dihydrolipolyl succinyltransferase
-
Mus musculus
2.3.1.61 DLST
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Mus musculus
2.3.1.61 E2 subcomponent of the alpha-ketoglutarate dehydrogenase complex
-
Mus musculus

Expression

EC Number Organism Comment Expression
2.3.1.61 Mus musculus enzyme protein levels significantly decrease in wild type mice after 4 weeks of angiotensin-II or 6 weeks of transversal aortic constriction. Enzyme levels significantly decrease in microRNA-146a wild-type mice on angiotensin-II administration down

General Information

EC Number General Information Comment Organism
2.3.1.61 physiological function enzyme overexpression in wild type mice protects against cardiac hypertrophy and dysfunction in vivo Mus musculus