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Literature summary extracted from

  • Zhou, Z.; Ma, S.
    Recent advances in the discovery of PqsD inhibitors as antimicrobial agents (2017), ChemMedChem, 12, 420-425 .
    View publication on PubMed

Application

EC Number Application Comment Organism
2.3.1.262 drug development antivirulence concepts through the inhibition of PqsD in the treatment of bacterial infections Pseudomonas aeruginosa

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.262 (2-nitrophenyl)(phenyl)methanol
-
 Pseudomonas aeruginosa
2.3.1.262 (2E)-3-(thiophen-3-yl)prop-2-enoic acid
-
 Pseudomonas aeruginosa
2.3.1.262 (2R)-2,4-dihydroxy-N-(3-[[4-hydroxy-4-(2-nitrophenyl)butyl]amino]-3-oxopropyl)-3,3-dimethylbutanamide
-
 Pseudomonas aeruginosa
2.3.1.262 (E)-1-(2-chloro-8-methylquinolin-3-yl)-N-[3-fluoro-4-(morpholin-4-yl)phenyl]methanimine
-
 Pseudomonas aeruginosa
2.3.1.262 (E)-1-(2-chloroquinolin-3-yl)-N-[3-fluoro-4-(morpholin-4-yl)phenyl]methanimine
-
 Pseudomonas aeruginosa
2.3.1.262 1-(2-nitrophenyl)propan-1-ol
-
 Pseudomonas aeruginosa
2.3.1.262 1-methyl-2-methylideneimidazolidine
-
 Pseudomonas aeruginosa
2.3.1.262 2-(3,4-dichlorobenzene-1-sulfonyl)-4-(1H-tetrazol-1-yl)pyrimidine
-
 Pseudomonas aeruginosa
2.3.1.262 2-(benzenesulfonyl)-4-(1H-tetrazol-1-yl)pyrimidine
-
 Pseudomonas aeruginosa
2.3.1.262 2-(hexane-1-sulfonyl)-4-(1H-1,2,3-triazol-1-yl)pyrimidine
-
 Pseudomonas aeruginosa
2.3.1.262 2-(methanesulfonyl)-4-(1H-1,2,3-triazol-1-yl)pyrimidine
-
 Pseudomonas aeruginosa
2.3.1.262 2-(methanesulfonyl)-4-(1H-tetrazol-1-yl)pyrimidine
-
 Pseudomonas aeruginosa
2.3.1.262 2-(methanesulfonyl)-4-(4-phenyl-1H-1,2,3-triazol-1-yl)pyrimidine
-
 Pseudomonas aeruginosa
2.3.1.262 2-(methanesulfonyl)-4-phenoxy-6-(1H-1,2,3-triazol-1-yl)pyrimidine
-
 Pseudomonas aeruginosa
2.3.1.262 2-[([1,1'-biphenyl]-4-carbonyl)amino]-3-chlorobenzoic acid
-
 Pseudomonas aeruginosa
2.3.1.262 2-[([1,1'-biphenyl]-4-carbonyl)amino]benzoic acid
-
 Pseudomonas aeruginosa
2.3.1.262 2-[3-(diethylsulfamoyl)benzamido]-6-hydroxybenzoic acid
-
 Pseudomonas aeruginosa
2.3.1.262 2-[3-hydroxy-3-(2-nitrophenyl)propyl]-1H-isoindole-1,3(2H)-dione
-
 Pseudomonas aeruginosa
2.3.1.262 3-(3,4-dihydroxyphenyl)propanoic acid
-
 Pseudomonas aeruginosa
2.3.1.262 3-(3-carboxypropanamido)-5-(4-methoxyphenyl)thiophene-2-carboxylic acid
-
 Pseudomonas aeruginosa
2.3.1.262 3-([[(1S)-1-carboxy-2-phenylethyl]carbamoyl]amino)-7-methoxy-4,5-dihydronaphtho[1,2-b]thiophene-2-carboxylic acid
-
 Pseudomonas aeruginosa
2.3.1.262 3-([[(1S)-1-carboxy-3-phenylpropyl]carbamoyl]amino)-5-(4-methoxyphenyl)thiophene-2-carboxylic acid
-
 Pseudomonas aeruginosa
2.3.1.262 3-([[(S)-carboxy(phenyl)methyl]carbamoyl]amino)-5-(4-methoxyphenyl)thiophene-2-carboxylic acid
-
 Pseudomonas aeruginosa
2.3.1.262 3-[[benzyl(ethyl)carbamoyl]amino]-5-(4-methoxyphenyl)thiophene-2-carboxylic acid
-
 Pseudomonas aeruginosa
2.3.1.262 4-[3-(diethylsulfamoyl)benzamido][1,1'-biphenyl]-3-carboxylic acid
-
 Pseudomonas aeruginosa
2.3.1.262 benzyl 3-(3,4-dihydroxyphenyl)propanoate
-
 Pseudomonas aeruginosa
2.3.1.262 methyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
-
 Pseudomonas aeruginosa
2.3.1.262 methyl 4-(3,4-dihydroxyphenyl)butanoate
-
 Pseudomonas aeruginosa
2.3.1.262 N-([(5R)-3-[3-fluoro-4-(morpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl)acetamide
-
 Pseudomonas aeruginosa
2.3.1.262 N-([2-carboxy-5-[4'-(hydroxymethyl)[1,1'-biphenyl]-4-yl]thiophen-3-yl]carbamoyl)-L-phenylalanine
-
 Pseudomonas aeruginosa
2.3.1.262 N-([2-carboxy-5-[4-(2-chloroacetamido)phenyl]thiophen-3-yl]carbamoyl)-L-phenylalanine
-
 Pseudomonas aeruginosa
2.3.1.262 N-[(2-carboxy-5-phenylthiophen-3-yl)carbamoyl]-L-phenylalanine
-
 Pseudomonas aeruginosa
2.3.1.262 N-[(2-carboxy-5-[4'-[hydroxy(2-nitrophenyl)methyl][1,1'-biphenyl]-4-yl]thiophen-3-yl)carbamoyl]-L-phenylalanine
-
 Pseudomonas aeruginosa
2.3.1.262 N-[[2-carboxy-5-(4-hydroxyphenyl)thiophen-3-yl]carbamoyl]-L-phenylalanine
-
 Pseudomonas aeruginosa
2.3.1.262 N-[[2-carboxy-5-(4-methoxy-2-methylphenyl)thiophen-3-yl]carbamoyl]-L-phenylalanine
-
 Pseudomonas aeruginosa
2.3.1.262 N-[[2-carboxy-5-(4-methoxyphenyl)thiophen-3-yl]carbamoyl]-4-chloro-L-phenylalanine
-
 Pseudomonas aeruginosa
2.3.1.262 N-[[2-carboxy-5-(4-methoxyphenyl)thiophen-3-yl]carbamoyl]-L-phenylalanine
-
 Pseudomonas aeruginosa
2.3.1.262 N-[[2-carboxy-5-(4-methoxyphenyl)thiophen-3-yl]carbamoyl]-L-tyrosine
-
 Pseudomonas aeruginosa
2.3.1.262 N-[[3-(furan-2-yl)-1H-pyrazol-5-yl]methyl]-2-(4-methylpiperazin-1-yl)pyrimidin-4-amine
-
 Pseudomonas aeruginosa
2.3.1.262 propan-2-yl 3-(3,4-dihydroxyphenyl)propanoate
-
 Pseudomonas aeruginosa

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.262 Pseudomonas aeruginosa P20582
-
-

Synonyms

EC Number Synonyms Comment Organism
2.3.1.262 PqsD
-
 Pseudomonas aeruginosa

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.3.1.262 0.0003
-
 pH and temperature not specified in the publication Pseudomonas aeruginosa 2-[3-hydroxy-3-(2-nitrophenyl)propyl]-1H-isoindole-1,3(2H)-dione
2.3.1.262 0.0003
-
 pH and temperature not specified in the publication Pseudomonas aeruginosa 4-[3-(diethylsulfamoyl)benzamido][1,1'-biphenyl]-3-carboxylic acid
2.3.1.262 0.00036
-
 pH and temperature not specified in the publication Pseudomonas aeruginosa N-([2-carboxy-5-[4'-(hydroxymethyl)[1,1'-biphenyl]-4-yl]thiophen-3-yl]carbamoyl)-L-phenylalanine
2.3.1.262 0.0004
-
 pH and temperature not specified in the publication Pseudomonas aeruginosa 2-(3,4-dichlorobenzene-1-sulfonyl)-4-(1H-tetrazol-1-yl)pyrimidine
2.3.1.262 0.0005
-
 pH and temperature not specified in the publication Pseudomonas aeruginosa N-[[2-carboxy-5-(4-methoxyphenyl)thiophen-3-yl]carbamoyl]-L-phenylalanine
2.3.1.262 0.0011
-
 pH and temperature not specified in the publication Pseudomonas aeruginosa 1-(2-nitrophenyl)propan-1-ol
2.3.1.262 0.0012
-
 pH and temperature not specified in the publication Pseudomonas aeruginosa 2-[3-(diethylsulfamoyl)benzamido]-6-hydroxybenzoic acid
2.3.1.262 0.0013
-
 pH and temperature not specified in the publication Pseudomonas aeruginosa 2-[([1,1'-biphenyl]-4-carbonyl)amino]benzoic acid
2.3.1.262 0.0014
-
 pH and temperature not specified in the publication Pseudomonas aeruginosa N-[(2-carboxy-5-[4'-[hydroxy(2-nitrophenyl)methyl][1,1'-biphenyl]-4-yl]thiophen-3-yl)carbamoyl]-L-phenylalanine
2.3.1.262 0.0017
-
 pH and temperature not specified in the publication Pseudomonas aeruginosa 2-(benzenesulfonyl)-4-(1H-tetrazol-1-yl)pyrimidine
2.3.1.262 0.0017
-
 pH and temperature not specified in the publication Pseudomonas aeruginosa 2-(hexane-1-sulfonyl)-4-(1H-1,2,3-triazol-1-yl)pyrimidine
2.3.1.262 0.002
-
 pH and temperature not specified in the publication Pseudomonas aeruginosa N-([2-carboxy-5-[4-(2-chloroacetamido)phenyl]thiophen-3-yl]carbamoyl)-L-phenylalanine
2.3.1.262 0.0032
-
 pH and temperature not specified in the publication Pseudomonas aeruginosa (2-nitrophenyl)(phenyl)methanol
2.3.1.262 0.0032
-
 pH and temperature not specified in the publication Pseudomonas aeruginosa 2-(methanesulfonyl)-4-phenoxy-6-(1H-1,2,3-triazol-1-yl)pyrimidine
2.3.1.262 0.0038
-
 pH and temperature not specified in the publication Pseudomonas aeruginosa N-[(2-carboxy-5-phenylthiophen-3-yl)carbamoyl]-L-phenylalanine
2.3.1.262 0.0059
-
 pH and temperature not specified in the publication Pseudomonas aeruginosa benzyl 3-(3,4-dihydroxyphenyl)propanoate
2.3.1.262 0.006
-
 pH and temperature not specified in the publication Pseudomonas aeruginosa 3-[[benzyl(ethyl)carbamoyl]amino]-5-(4-methoxyphenyl)thiophene-2-carboxylic acid
2.3.1.262 0.0062
-
 pH and temperature not specified in the publication Pseudomonas aeruginosa 2-[([1,1'-biphenyl]-4-carbonyl)amino]-3-chlorobenzoic acid
2.3.1.262 0.007
-
 pH and temperature not specified in the publication Pseudomonas aeruginosa 3-(3-carboxypropanamido)-5-(4-methoxyphenyl)thiophene-2-carboxylic acid
2.3.1.262 0.0075
-
 pH and temperature not specified in the publication Pseudomonas aeruginosa N-[[2-carboxy-5-(4-methoxy-2-methylphenyl)thiophen-3-yl]carbamoyl]-L-phenylalanine
2.3.1.262 0.0079
-
 pH and temperature not specified in the publication Pseudomonas aeruginosa (2R)-2,4-dihydroxy-N-(3-[[4-hydroxy-4-(2-nitrophenyl)butyl]amino]-3-oxopropyl)-3,3-dimethylbutanamide
2.3.1.262 0.0079
-
 pH and temperature not specified in the publication Pseudomonas aeruginosa methyl 4-(3,4-dihydroxyphenyl)butanoate
2.3.1.262 0.0086
-
 pH and temperature not specified in the publication Pseudomonas aeruginosa propan-2-yl 3-(3,4-dihydroxyphenyl)propanoate
2.3.1.262 0.0129
-
 pH and temperature not specified in the publication Pseudomonas aeruginosa (E)-1-(2-chloroquinolin-3-yl)-N-[3-fluoro-4-(morpholin-4-yl)phenyl]methanimine
2.3.1.262 0.0138
-
 pH and temperature not specified in the publication Pseudomonas aeruginosa N-[[2-carboxy-5-(4-methoxyphenyl)thiophen-3-yl]carbamoyl]-4-chloro-L-phenylalanine
2.3.1.262 0.0156
-
 pH and temperature not specified in the publication Pseudomonas aeruginosa (E)-1-(2-chloro-8-methylquinolin-3-yl)-N-[3-fluoro-4-(morpholin-4-yl)phenyl]methanimine
2.3.1.262 0.0159
-
 pH and temperature not specified in the publication Pseudomonas aeruginosa N-([(5R)-3-[3-fluoro-4-(morpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl)acetamide
2.3.1.262 0.0216
-
 pH and temperature not specified in the publication Pseudomonas aeruginosa N-[[2-carboxy-5-(4-hydroxyphenyl)thiophen-3-yl]carbamoyl]-L-phenylalanine
2.3.1.262 0.0237
-
 pH and temperature not specified in the publication Pseudomonas aeruginosa 3-([[(1S)-1-carboxy-2-phenylethyl]carbamoyl]amino)-7-methoxy-4,5-dihydronaphtho[1,2-b]thiophene-2-carboxylic acid
2.3.1.262 0.027
-
 pH and temperature not specified in the publication Pseudomonas aeruginosa 3-(3,4-dihydroxyphenyl)propanoic acid
2.3.1.262 0.029
-
 pH and temperature not specified in the publication Pseudomonas aeruginosa N-[[2-carboxy-5-(4-methoxyphenyl)thiophen-3-yl]carbamoyl]-L-tyrosine
2.3.1.262 0.051
-
 pH and temperature not specified in the publication Pseudomonas aeruginosa methyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate

General Information

EC Number General Information Comment Organism
2.3.1.262 metabolism PqsD is an enzyme essential for the Pseudomonas aeruginosa quorum-sensing apparatus, which catalyzes the final and key step in the biosynthesis of 4-hydroxy-2-heptylquinolone, which is a signal molecule of the Pseudomonas aeruginosa quorum-sensing system Pseudomonas aeruginosa