Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Tengg, M.; Stecher, H.; Offner, L.; Plasch, K.; Anderl, F.; Weber, H.; Schwab, H.; Gruber-Khadjawi, M.
    Methyltransferases green catalysts for Friedel-Crafts alkylations (2016), ChemCatChem, 8, 1354-1360 .
No PubMed abstract available

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.304 expression in Escherichia coli K12 Pseudomonas fluorescens
2.1.1.304 expression in Escherichia coli K12 Streptomyces lavendulae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.304 S-adenosyl-L-methionine + L-tyrosine Streptomyces lavendulae the enzyme is highly selective with regard to their natural substrate. The enzyme is involved in the biosynthesis of 3'-methyltyrosine, which is the precursor of the tetrahydroisoquinoline moiety in Saframycin (antibiotic) S-adenosyl-L-homocysteine + 3-methyl-L-tyrosine
-
 ?
2.1.1.304 S-adenosyl-L-methionine + L-tyrosine Pseudomonas fluorescens the enzyme is involved in the biosynthesis of 3'-methyltyrosine, which is the precursor of the tetrahydroisoquinoline moiety in Safracin (antibiotic) S-adenosyl-L-homocysteine + 3-methyl-L-tyrosine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.304 Pseudomonas fluorescens
-
-
-
2.1.1.304 Streptomyces lavendulae B0CN31
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.304 additional information activity with L-DOPA is 1% of the activity with L-tyrosine Streptomyces lavendulae ?
-
-
2.1.1.304 additional information activity with L-DOPA is 2% of the activity with L-tyrosine Pseudomonas fluorescens ?
-
-
2.1.1.304 S-adenosyl-L-methionine + D-tyrosine 24% of the activity as compared to L-tyrosine Streptomyces lavendulae S-adenosyl-L-homocysteine + 3-methyl-D-tyrosine
-
 ?
2.1.1.304 S-adenosyl-L-methionine + D-tyrosine 64% of the activity as compared to L-tyrosine Pseudomonas fluorescens S-adenosyl-L-homocysteine + 3-methyl-D-tyrosine
-
 ?
2.1.1.304 S-adenosyl-L-methionine + L-tyrosine
-
 Pseudomonas fluorescens S-adenosyl-L-homocysteine + 3-methyl-L-tyrosine
-
 ?
2.1.1.304 S-adenosyl-L-methionine + L-tyrosine the enzyme is highly selective with regard to their natural substrate. The enzyme is involved in the biosynthesis of 3'-methyltyrosine, which is the precursor of the tetrahydroisoquinoline moiety in Saframycin (antibiotic) Streptomyces lavendulae S-adenosyl-L-homocysteine + 3-methyl-L-tyrosine
-
 ?
2.1.1.304 S-adenosyl-L-methionine + L-tyrosine the enzyme is involved in the biosynthesis of 3'-methyltyrosine, which is the precursor of the tetrahydroisoquinoline moiety in Safracin (antibiotic) Pseudomonas fluorescens S-adenosyl-L-homocysteine + 3-methyl-L-tyrosine
-
 ?
2.1.1.304 S-adenosyl-L-methionine + L-tyrosine the enzyme is highly selective with regard to their natural substrate Streptomyces lavendulae S-adenosyl-L-homocysteine + 3-methyl-L-tyrosine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.304 SacF
-
 Pseudomonas fluorescens
2.1.1.304 SfmM2
-
 Streptomyces lavendulae

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.1.1.304 30
-
 assay at Pseudomonas fluorescens
2.1.1.304 30
-
 assay at Streptomyces lavendulae

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.1.304 7
-
 assay at Pseudomonas fluorescens
2.1.1.304 7
-
 assay at Streptomyces lavendulae

General Information

EC Number General Information Comment Organism
2.1.1.304 physiological function the enzyme is involved in the biosynthesis of 3'-methyltyrosine, which is the precursor of the tetrahydroisoquinoline moiety in Safracin (antibiotic) Pseudomonas fluorescens
2.1.1.304 physiological function the enzyme is involved in the biosynthesis of 3'-methyltyrosine, which is the precursor of the tetrahydroisoquinoline moiety in Saframycin (antibiotic) Streptomyces lavendulae