Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Fricke, J.; Sherwood, A.; Kargbo, R.; Orry, A.; Blei, F.; Naschberger, A.; Rupp, B.; Hoffmeister, D.
    Enzymatic route toward 6-methylated baeocystin and psilocybin (2019), ChemBioChem, 20, 2824-2829 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.345 expression in Escherichia coli Psilocybe cubensis

Protein Variants

EC Number Protein Variants Comment Organism
2.1.1.345 D161A the variant is as active as the wild-type enzyme in in vitro assays Psilocybe cubensis
2.1.1.345 N183A the variant is catalytically inactive Psilocybe cubensis
2.1.1.345 R75A the variant is catalytically inactive Psilocybe cubensis
2.1.1.345 S196A inactive variant Psilocybe cubensis
2.1.1.345 Y187A the variant is catalytically inactive Psilocybe cubensis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.345 2 S-adenosyl-L-methionine + 4-hydroxytryptamine 4-phosphate Psilocybe cubensis
-
 2 S-adenosyl-L-homocysteine + psilocybin
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.345 Psilocybe cubensis P0DPA9
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.345
-
 Psilocybe cubensis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.345 2 S-adenosyl-L-methionine + 4-hydroxytryptamine 4-phosphate
-
 Psilocybe cubensis 2 S-adenosyl-L-homocysteine + psilocybin
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.345 PsiM
-
 Psilocybe cubensis