EC Number | Cloned (Comment) | Organism |
---|---|---|
2.3.1.180 | expressed in Escherichia coli strains DH10B (native enzyme) and BL21(DE3) (selenomethionine-substituted enzyme) | Escherichia coli |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.180 | (E)-1-(6-chloropyridin-3-yl)-N-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)methylene)methanamine | - |
Escherichia coli | |
2.3.1.180 | (E)-1-(6-chloropyridin-3-yl)-N-((3,4-dihydro-2Hbenzo[b][1,4]dioxepin-7-yl)methylene)methanamine | - |
Escherichia coli | |
2.3.1.180 | (E)-4-chloro-N-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)methylene)pyridin-2-amine | - |
Escherichia coli | |
2.3.1.180 | (E)-5-chloro-N-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)methylene)pyridin-2-amine | - |
Escherichia coli | |
2.3.1.180 | (E)-6-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)-methyleneamino)nicotinonitrile | - |
Escherichia coli | |
2.3.1.180 | (E)-N-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)-methylene)-3-methylpyridin-2-amine | - |
Escherichia coli | |
2.3.1.180 | (E)-N-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)-methylene)-4-methylpyridin-2-amine | - |
Escherichia coli | |
2.3.1.180 | (E)-N-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)-methylene)-5-(trifluoromethyl)pyridin-2-amine | - |
Escherichia coli | |
2.3.1.180 | (E)-N-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)-methylene)pyridin-3-amine | - |
Escherichia coli | |
2.3.1.180 | (E)-tert-butyl 4-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)methyleneamino)piperidine-1-carboxylate | - |
Escherichia coli | |
2.3.1.180 | 2,4-dibromo-6-[(E)-(2-[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazinylidene)methyl]phenol | - |
Escherichia coli | |
2.3.1.180 | 2-(2-methyl-5-nitro-1H-imidazol-1-yl)-N'-[(E)-(3,4,5-trimethylphenyl)methylidene]acetohydrazide | - |
Escherichia coli | |
2.3.1.180 | 2-(decane-1-sulfonyl)acetamide | FAS20013 | Escherichia coli | |
2.3.1.180 | 4,5-dichloro-3H-1,2-dithiol-3-one | HR45 | Escherichia coli | |
2.3.1.180 | 4-[(Z)-(cyclohexylimino)methyl]benzene-1,3-diol | YKAs3003 | Escherichia coli | |
2.3.1.180 | 6-[(2,6-dichlorophenyl)methoxy]-3-(phenylsulfanyl)-1H-indole-2-carboxylic acid | SB418011 | Escherichia coli | |
2.3.1.180 | FAS20013 | - |
Escherichia coli | |
2.3.1.180 | HR45 | - |
Escherichia coli | |
2.3.1.180 | SB418011 | - |
Escherichia coli | |
2.3.1.180 | YKAs3003 | - |
Escherichia coli |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.180 | acetyl-CoA + a malonyl-[acyl-carrier protein] | Escherichia coli | - |
an acetoacetyl-[acyl-carrier protein] + CoA + CO2 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.180 | Escherichia coli | P0A6R0 | - |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.3.1.180 | Q-Sepharose, MonoQ, and hydroxyapatite column chromatographies (native enzyme) or Ni-NTA agarose column chromatography (selenomethionine-substituted enzyme) | Escherichia coli |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.180 | acetyl-CoA + a malonyl-[acyl-carrier protein] | - |
Escherichia coli | an acetoacetyl-[acyl-carrier protein] + CoA + CO2 | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.3.1.180 | beta-ketoacyl-acyl carrier protein synthase III | - |
Escherichia coli |
2.3.1.180 | FabH | - |
Escherichia coli |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
2.3.1.180 | 0.0021 | - |
at pH 7.0 and 37°C | Escherichia coli | (E)-tert-butyl 4-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)methyleneamino)piperidine-1-carboxylate | |
2.3.1.180 | 0.0038 | - |
at pH 7.0 and 37°C | Escherichia coli | (E)-N-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)-methylene)-5-(trifluoromethyl)pyridin-2-amine | |
2.3.1.180 | 0.0067 | - |
at pH 7.0 and 37°C | Escherichia coli | (E)-1-(6-chloropyridin-3-yl)-N-((3,4-dihydro-2Hbenzo[b][1,4]dioxepin-7-yl)methylene)methanamine | |
2.3.1.180 | 0.0074 | - |
at pH 7.0 and 37°C | Escherichia coli | (E)-N-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)-methylene)-3-methylpyridin-2-amine | |
2.3.1.180 | 0.0099 | - |
at pH 7.0 and 37°C | Escherichia coli | (E)-6-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)-methyleneamino)nicotinonitrile | |
2.3.1.180 | 0.0123 | - |
at pH 7.0 and 37°C | Escherichia coli | (E)-4-chloro-N-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)methylene)pyridin-2-amine | |
2.3.1.180 | 0.0128 | - |
at pH 7.0 and 37°C | Escherichia coli | (E)-5-chloro-N-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)methylene)pyridin-2-amine | |
2.3.1.180 | 0.0145 | - |
at pH 7.0 and 37°C | Escherichia coli | (E)-N-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)-methylene)pyridin-3-amine | |
2.3.1.180 | 0.0151 | - |
at pH 7.0 and 37°C | Escherichia coli | (E)-N-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)-methylene)-4-methylpyridin-2-amine |