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Literature summary extracted from

  • Jiang, J.; Kanabar, V.; Padilla, B.; Man, F.; Pitchford, S.C.; Page, C.P.; Wagner, G.K.
    Uncharged nucleoside inhibitors of beta-1,4-galactosyltransferase with activity in cells (2016), Chem. Commun. (Camb.), 52, 3955-3958 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.90 1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-5-(1-methyl-1H-indol-4-yl)pyrimidine-2,4(1H,3H)-dione
-
 Homo sapiens
2.4.1.90 1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-5-(1H-indazol-4-yl)pyrimidine-2,4(1H,3H)-dione
-
 Homo sapiens
2.4.1.90 1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-5-(1H-indol-4-yl)pyrimidine-2,4(1H,3H)-dione
-
 Homo sapiens
2.4.1.90 1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-5-(1H-indol-5-yl)pyrimidine-2,4(1H,3H)-dione
-
 Homo sapiens
2.4.1.90 1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-5-(1H-indol-6-yl)pyrimidine-2,4(1H,3H)-dione
-
 Homo sapiens
2.4.1.90 1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)pyrimidine-2,4(1H,3H)-dione
-
 Homo sapiens
2.4.1.90 1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-5-(isoquinolin-4-yl)pyrimidine-2,4(1H,3H)-dione
-
 Homo sapiens
2.4.1.90 1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-5-(pyridin-3-yl)pyrimidine-2,4(1H,3H)-dione
-
 Homo sapiens
2.4.1.90 1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-5-(pyridin-4-yl)pyrimidine-2,4(1H,3H)-dione
-
 Homo sapiens
2.4.1.90 2-((5-(1,2,3,4-tetrahydro-1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-2,4-dioxopyrimidin-5-yl)thiophen-2-yl)methylamino)-3-(1H-indol-3-yl)propanoic acid
-
 Homo sapiens
2.4.1.90 2-((5-(1,2,3,4-tetrahydro-1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-2,4-dioxopyrimidin-5-yl)thiophen-2-yl)methylamino)-4-methylpentanoic acid
-
 Homo sapiens
2.4.1.90 2-((5-(1,2,3,4-tetrahydro-1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-2,4-dioxopyrimidin-5-yl)thiophen-2-yl)methylamino)-6-aminohexanoic acid
-
 Homo sapiens
2.4.1.90 2-((5-(1,2,3,4-tetrahydro-1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-2,4-dioxopyrimidin-5-yl)thiophen-2-yl)methylamino)acetic acid
-
 Homo sapiens
2.4.1.90 5-(1,2,3,4-tetrahydro-1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-2,4-dioxopyrimidin-5-yl)thiophene-2-carbaldehyde
-
 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.90 Mn2+ 5 mM used in assay conditions Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.90 UDP-alpha-D-galactose + N-acetyl-D-glucosamine Homo sapiens
-
 UDP + N-acetyllactosamine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.90 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.90 additional information no activity with 5-(indol-4-yl)-UDP-alpha-D-galactose Homo sapiens ?
-
-
2.4.1.90 UDP-alpha-D-galactose + N-acetyl-D-glucosamine
-
 Homo sapiens UDP + N-acetyllactosamine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.90 beta-1,4-galactosyltransferase
-
 Homo sapiens
2.4.1.90 beta-1,4-GalT
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.4.1.90 0.163
-
 pH and temperature not specified in the publication Homo sapiens 1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-5-(1-methyl-1H-indol-4-yl)pyrimidine-2,4(1H,3H)-dione
2.4.1.90 0.207
-
 pH and temperature not specified in the publication Homo sapiens 1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-5-(1H-indol-4-yl)pyrimidine-2,4(1H,3H)-dione
2.4.1.90 0.25
-
 pH and temperature not specified in the publication Homo sapiens 1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-5-(1H-indol-6-yl)pyrimidine-2,4(1H,3H)-dione
2.4.1.90 0.284
-
 pH and temperature not specified in the publication Homo sapiens 2-((5-(1,2,3,4-tetrahydro-1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-2,4-dioxopyrimidin-5-yl)thiophen-2-yl)methylamino)-3-(1H-indol-3-yl)propanoic acid
2.4.1.90 1
-
 IC50 above 1.0 mM, pH and temperature not specified in the publication Homo sapiens 1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-5-(1H-indazol-4-yl)pyrimidine-2,4(1H,3H)-dione
2.4.1.90 1
-
 IC50 above 1.0 mM, pH and temperature not specified in the publication Homo sapiens 1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-5-(1H-indol-5-yl)pyrimidine-2,4(1H,3H)-dione
2.4.1.90 1
-
 IC50 above 1.0 mM, pH and temperature not specified in the publication Homo sapiens 1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)pyrimidine-2,4(1H,3H)-dione
2.4.1.90 1
-
 IC50 above 1.0 mM, pH and temperature not specified in the publication Homo sapiens 1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-5-(isoquinolin-4-yl)pyrimidine-2,4(1H,3H)-dione
2.4.1.90 1
-
 IC50 above 1.0 mM, pH and temperature not specified in the publication Homo sapiens 1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-5-(pyridin-3-yl)pyrimidine-2,4(1H,3H)-dione
2.4.1.90 1
-
 IC50 above 1.0 mM, pH and temperature not specified in the publication Homo sapiens 1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-5-(pyridin-4-yl)pyrimidine-2,4(1H,3H)-dione
2.4.1.90 1
-
 IC50 above 1.0 mM, pH and temperature not specified in the publication Homo sapiens 2-((5-(1,2,3,4-tetrahydro-1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-2,4-dioxopyrimidin-5-yl)thiophen-2-yl)methylamino)-3-(1H-indol-3-yl)propanoic acid
2.4.1.90 1
-
 IC50 above 1.0 mM, pH and temperature not specified in the publication Homo sapiens 2-((5-(1,2,3,4-tetrahydro-1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-2,4-dioxopyrimidin-5-yl)thiophen-2-yl)methylamino)-4-methylpentanoic acid
2.4.1.90 1
-
 IC50 above 1.0 mM, pH and temperature not specified in the publication Homo sapiens 2-((5-(1,2,3,4-tetrahydro-1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-2,4-dioxopyrimidin-5-yl)thiophen-2-yl)methylamino)-6-aminohexanoic acid
2.4.1.90 1
-
 IC50 above 1.0 mM, pH and temperature not specified in the publication Homo sapiens 2-((5-(1,2,3,4-tetrahydro-1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-2,4-dioxopyrimidin-5-yl)thiophen-2-yl)methylamino)acetic acid
2.4.1.90 1
-
 IC50 above 1.0 mM, pH and temperature not specified in the publication Homo sapiens 5-(1,2,3,4-tetrahydro-1-((2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-2,4-dioxopyrimidin-5-yl)thiophene-2-carbaldehyde