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Literature summary extracted from

  • Turpin-Nolan, S.M.; Hammerschmidt, P.; Chen, W.; Jais, A.; Timper, K.; Awazawa, M.; Brodesser, S.; Bruening, J.C.
    CerS1-derived C18 0 ceramide in skeletal muscle promotes obesity-induced insulin resistance (2019), Cell Rep., 26, 1-10.e7 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.299 stearoyl-CoA + dihydroceramide Mus musculus
-
 N-(stearoyl)-dihydroceramide + CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.299 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.299 skeletal muscle
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.299 stearoyl-CoA + dihydroceramide
-
 Mus musculus N-(stearoyl)-dihydroceramide + CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.299 ceramide synthase 1
-
 Mus musculus
2.3.1.299 CerS1
-
 Mus musculus

Expression

EC Number Organism Comment Expression
2.3.1.299 Mus musculus enzyme expression is increased in skeletal muscle of obese mice up

General Information

EC Number General Information Comment Organism
2.3.1.299 malfunction enzyme deletion, and the consequent reduction of C18:0 acyl-chain ceramide specifically in skeletal muscle, enhances whole-body glucose metabolism in obesity through increased muscle-derived circulating Fgf21 protein concentrations. Enzyme deficiency protects from insulin resistance Mus musculus