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Literature summary extracted from

  • Mounce, B.C.; Poirier, E.Z.; Passoni, G.; Simon-Loriere, E.; Cesaro, T.; Prot, M.; Stapleford, K.A.; Moratorio, G.; Sakuntabhai, A.; Levraud, J.P.; Vignuzzi, M.
    Interferon-induced spermidine-spermine acetyltransferase and polyamine depletion restrict Zika and chikungunya viruses (2016), Cell Host Microbe, 20, 167-177 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.57 acetyl-CoA + spermidine Homo sapiens
-
 CoA + N1-acetylspermidine
-
 ?
2.3.1.57 acetyl-CoA + spermine Homo sapiens
-
 CoA + N1-acetylspermine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.57 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.57 Huh-7 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.57 acetyl-CoA + spermidine
-
 Homo sapiens CoA + N1-acetylspermidine
-
 ?
2.3.1.57 acetyl-CoA + spermine
-
 Homo sapiens CoA + N1-acetylspermine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.57 SAT1
-
 Homo sapiens
2.3.1.57 spermidine-spermine acetyltransferase
-
 Homo sapiens
2.3.1.57 SSAT
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.3.1.57 Homo sapiens the enzyme is upregulated by type I interferon beta stimulation (10000 units/ml for 16 h) or treatment with N1,N11-diethylnorspermine (0.01 mM for 16 h) up

General Information

EC Number General Information Comment Organism
2.3.1.57 physiological function the enzyme restricts chikungunya virus and Zika virus replication. The enzyme depletes spermidine and spermine to restrict RNA virus replication Homo sapiens