Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Xu, Y.; Anderson, D.; Ye, Y.
    The HECT domain ubiquitin ligase HUWE1 targets unassembled soluble proteins for degradation (2016), Cell Discov., 2, 16040 .
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.2.26 cytoplasm
-
 Homo sapiens 5737
-

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.26 Homo sapiens Q7Z6Z7 isoform Huwe1
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.2.26 HEK-293T cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.26 [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [Ubl4A]-L-lysine Ubl4A, i.e. subunit of the Bag6 chaperone holdase complex. HUWE1 degrades unassembled Ubl4A in the cytoplasm Homo sapiens [E2 ubiquitin-conjugating enzyme]-L-cysteine + [Ubl4A]-N6-ubiquitinyl-L-lysine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.2.26 Huwe1
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.3.2.26 physiological function HUWE1 is a ubiquitin ligase for substrates bearing unshielded, hydrophobic segments. Many endogenous HUWE1 substrates form multi-protein complexes that function in the nucleus although HUWE1 itself is cytoplasmically localized. Inhibition of nuclear entry enhances HUWE1-mediated ubiquitination and degradation Homo sapiens