Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Gu, L.; Zhu, Y.; Lin, X.; Li, Y.; Cui, K.; Prochownik, E.; Li, Y.
    Amplification of glyceronephosphate O-acyltransferase and recruitment of USP30 stabilize DRP1 to promote hepatocarcinogenesis (2018), Cancer Res., 78, 5808-5819 .
    View publication on PubMed

Application

EC Number Application Comment Organism
2.3.1.42 medicine the enzyme is highly correlated with poor clinical outcome in patients with hepatocellular carcinoma Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.42 peroxisome
-
 Homo sapiens 5777
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.42 acyl-CoA + glycerone phosphate Homo sapiens
-
 CoA + acylglycerone phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.42 Homo sapiens O15228
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.42 BEL-7402 cell
-
 Homo sapiens
-
2.3.1.42 FHCC-98 cell
-
 Homo sapiens
-
2.3.1.42 HCCLM-9 cell
-
 Homo sapiens
-
2.3.1.42 HEP-3B cell
-
 Homo sapiens
-
2.3.1.42 Hep-G2 cell
-
 Homo sapiens
-
2.3.1.42 hepatoma cell
-
 Homo sapiens
-
2.3.1.42 HL-7702 cell
-
 Homo sapiens
-
2.3.1.42 Huh-7 cell
-
 Homo sapiens
-
2.3.1.42 MHCC97-L cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.42 acyl-CoA + glycerone phosphate
-
 Homo sapiens CoA + acylglycerone phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.42 ? x * 70000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.3.1.42 glyceronephosphate O-acyltransferase
-
 Homo sapiens
2.3.1.42 GNPAT
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.3.1.42 Homo sapiens the enzyme is upregulated in patients with hepatocellular carcinoma up

General Information

EC Number General Information Comment Organism
2.3.1.42 physiological function the enzyme recruits the enzyme USP30, which deubiquitylates and stabilizes dynamin-related protein 1, thereby facilitating regulation of mitochondrial morphology, lipid metabolism, and hepatocarcinogenesis Homo sapiens