EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
2.3.1.5 | additional information | native gene contains a c.580delG frameshift mutation leading to expression of a truncated protein. Artificial reintroduction of residue G580 in the NAT3 gene leads to a functional enzyme able to acetylate several arylamine drugs | Bacillus anthracis |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.3.1.5 | 0.0134 | - |
hydralazine | artificial full-length enzyme, pH 7.5, 37°C | Bacillus anthracis | |
2.3.1.5 | 0.0165 | - |
2-Aminofluorene | artificial full-length enzyme, pH 7.5, 37°C | Bacillus anthracis | |
2.3.1.5 | 0.189 | - |
4-Aminosalicylate | artificial full-length enzyme, pH 7.5, 37°C | Bacillus anthracis | |
2.3.1.5 | 0.349 | - |
isoniazid | artificial full-length enzyme, pH 7.5, 37°C | Bacillus anthracis |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.5 | Bacillus anthracis | A0A0J1HNH1 | isoform NAT3, native gene contains a c.580delG frameshift mutation leading to expression of an inactive truncated protein | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.5 | 4-nitrophenyl acetate + 2-aminofluorene | - |
Bacillus anthracis | 4-nitrophenol + N-acetyl-2-aminofluorene | - |
? | |
2.3.1.5 | 4-nitrophenyl acetate + 4-aminosalicylate | - |
Bacillus anthracis | 4-nitrophenol + N-acetyl-4-aminosalicylate | - |
? | |
2.3.1.5 | 4-nitrophenyl acetate + hydralazine | - |
Bacillus anthracis | 4-nitrophenol + N-acetyl-hydralazine | - |
? | |
2.3.1.5 | 4-nitrophenyl acetate + isoniazid | - |
Bacillus anthracis | 4-nitrophenol + N-acetylisoniazid | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.3.1.5 | (BACAN)NAT3 | - |
Bacillus anthracis |
2.3.1.5 | ABW01_24350 | - |
Bacillus anthracis |
2.3.1.5 | NAT3 | - |
Bacillus anthracis |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.3.1.5 | 0.43 | - |
2-Aminofluorene | artificial full-length enzyme, pH 7.5, 37°C | Bacillus anthracis | |
2.3.1.5 | 0.51 | - |
isoniazid | artificial full-length enzyme, pH 7.5, 37°C | Bacillus anthracis | |
2.3.1.5 | 0.6 | - |
4-Aminosalicylate | artificial full-length enzyme, pH 7.5, 37°C | Bacillus anthracis | |
2.3.1.5 | 0.63 | - |
hydralazine | artificial full-length enzyme, pH 7.5, 37°C | Bacillus anthracis |
EC Number | kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.3.1.5 | 1.5 | - |
isoniazid | artificial full-length enzyme, pH 7.5, 37°C | Bacillus anthracis | |
2.3.1.5 | 3.3 | - |
4-Aminosalicylate | artificial full-length enzyme, pH 7.5, 37°C | Bacillus anthracis | |
2.3.1.5 | 26.1 | - |
2-Aminofluorene | artificial full-length enzyme, pH 7.5, 37°C | Bacillus anthracis | |
2.3.1.5 | 47 | - |
hydralazine | artificial full-length enzyme, pH 7.5, 37°C | Bacillus anthracis |