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Literature summary extracted from

  • Valerio, D.; Xu, H.; Eisold, M.; Woolthuis, C.; Pandita, T.; Armstrong, S.
    Histone acetyltransferase activity of MOF is required for adult but not early fetal hematopoiesis in mice (2017), Blood, 129, 48-59 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.48 acetyl-CoA + [histone H4]-L-lysin16 Mus musculus
-
 CoA + [histone H4]-N6-acetyl-L-lysine16
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.48 Mus musculus Q9D1P2
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.48 hematopoietic stem cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.48 acetyl-CoA + [histone H4]-L-lysin16
-
 Mus musculus CoA + [histone H4]-N6-acetyl-L-lysine16
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.48 K(lysine) acetyltransferase 8
-
 Mus musculus
2.3.1.48 KAT8
-
 Mus musculus
2.3.1.48 Mof
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.3.1.48 malfunction homozygous enzyme loss leads to lethal hematopoietic failure in mice at an early postnatal stage. Enzyme loss in adult mice results in dramatic hematopoietic failure Mus musculus
2.3.1.48 physiological function the enzyme is a developmental-stage-specific chromatin regulator whose activity is essential for adult but not early and midgestational murine hematopoietic maintenance. Enzyme activity is required for adult hematopoietic cell survival Mus musculus