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Literature summary extracted from

  • Thangavelu, B.; Mutthamsetty, V.; Wang, Q.; Viola, R.E.
    Design and optimization of aspartate N-acetyltransferase inhibitors for the potential treatment of Canavan disease (2017), Bioorg. Med. Chem., 25, 870-885 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.17 (2S)-2-(3-phenylpropanamido)butanedioic acid
-
 Homo sapiens
2.3.1.17 (2S)-2-(3-phenylpropanamido)pentanedioic acid
-
 Homo sapiens
2.3.1.17 (2S)-2-[[(benzyloxy)carbonyl]amino]butanedioic acid
-
 Homo sapiens
2.3.1.17 (2S)-2-[[(benzyloxy)carbonyl]amino]pentanedioic acid
-
 Homo sapiens
2.3.1.17 4-aminomethyl(N-carboethyl,N-4-carboxy-2,6-dichlorobenzyl)phthalate
-
 Homo sapiens
2.3.1.17 N-(2,6-dibromo-4-carboxybenzyl)-N-carboxyethyl-3,4-dicarboxybenzylamine
-
 Homo sapiens
2.3.1.17 N-(2,6-dichloro-4-carboxybenzyl)-N-carboxyethyl-3,4-dicarboxybenzylamine
-
 Homo sapiens
2.3.1.17 N-carbobenzyloxy-L-aspartic acid
-
 Homo sapiens
2.3.1.17 N-carbobenzyloxy-L-glutamic acid
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.17 Homo sapiens Q8N9F0
-
-

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.1.17 0.0006
-
 4-aminomethyl(N-carboethyl,N-4-carboxy-2,6-dichlorobenzyl)phthalate pH 7.4, temperature not specified in the publication Homo sapiens
2.3.1.17 0.00061
-
 N-(2,6-dichloro-4-carboxybenzyl)-N-carboxyethyl-3,4-dicarboxybenzylamine pH 7.4, temperature not specified in the publication Homo sapiens
2.3.1.17 0.00077
-
 N-(2,6-dibromo-4-carboxybenzyl)-N-carboxyethyl-3,4-dicarboxybenzylamine pH 7.4, temperature not specified in the publication Homo sapiens
2.3.1.17 0.012
-
 (2S)-2-[[(benzyloxy)carbonyl]amino]pentanedioic acid pH 7.4, temperature not specified in the publication Homo sapiens
2.3.1.17 0.012
-
 N-carbobenzyloxy-L-glutamic acid pH 7.4, temperature not specified in the publication Homo sapiens
2.3.1.17 0.017
-
 N-carbobenzyloxy-L-aspartic acid pH 7.4, temperature not specified in the publication Homo sapiens
2.3.1.17 0.017
-
 (2S)-2-[[(benzyloxy)carbonyl]amino]butanedioic acid pH 7.4, temperature not specified in the publication Homo sapiens
2.3.1.17 0.031
-
 (2S)-2-(3-phenylpropanamido)butanedioic acid pH 7.4, temperature not specified in the publication Homo sapiens
2.3.1.17 0.038
-
 (2S)-2-(3-phenylpropanamido)pentanedioic acid pH 7.4, temperature not specified in the publication Homo sapiens