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Literature summary extracted from

  • Tomar, J.; Hosur, R.
    Polyamine acetylation and substrate-induced oligomeric states in histone acetyltransferase of multiple drug resistant Acinetobacter baumannii (2020), Biochimie, 168, 268-276 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.48 expressed in Escherichia coli BL21(DE3) cells Acinetobacter baumannii

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.48 32000
-
 enzyme-putrescine complex, gel filtration Acinetobacter baumannii
2.3.1.48 64000
-
 enzyme alone or in complex with spermine, gel filtration Acinetobacter baumannii

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.48 Acinetobacter baumannii
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.48 affinity column chromatography and Superdex 75 gel filtration Acinetobacter baumannii

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.48 acetyl-CoA + putrescine
-
 Acinetobacter baumannii ?
-
 ?
2.3.1.48 acetyl-CoA + spermidine
-
 Acinetobacter baumannii ?
-
 ?
2.3.1.48 acetyl-CoA + spermine
-
 Acinetobacter baumannii ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.48 dimer or tetramer the enzyme exists as dimer in solution and self-assembles into tetramer in the spermine-, spermidine- and kanamycin-bound form Acinetobacter baumannii
2.3.1.48 homodimer 2 * 16000, SDS-PAGE Acinetobacter baumannii

Synonyms

EC Number Synonyms Comment Organism
2.3.1.48 Hpa2
-
 Acinetobacter baumannii

General Information

EC Number General Information Comment Organism
2.3.1.48 physiological function the enzyme downregulates biofilm formation in Acinetobacter baumannii via polyamine acetylation Acinetobacter baumannii