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Literature summary extracted from

  • Inaba, K.; Ito, K.
    Structure and mechanisms of the DsbB-DsbA disulfide bond generation machine (2008), Biochim. Biophys. Acta Mol. Cell Res., 1783, 520-529 .
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.8.5.9 cytoplasmic membrane
-
 Escherichia coli
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.5.9 a [DsbA protein] with reduced L-cysteine residues + a [DsbB protein] carrying a disulfide bond Escherichia coli
-
 a [DsbA protein] carrying a disulfide bond + a [DsbB protein] with reduced L-cysteine residues
-
 ?
1.8.5.9 a [DsbA protein] with reduced L-cysteine residues + ubiquinone Escherichia coli overall reaction a [DsbA protein] carrying a disulfide bond + ubiquinol
-
 ?
1.8.5.9 a [DsbB protein] with reduced L-cysteine residues + ubiquinone Escherichia coli
-
 a [DsbB protein] carrying a disulfide bond + ubiquinol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.8.5.9 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.5.9 a [DsbA protein] with reduced L-cysteine residues + a [DsbB protein] carrying a disulfide bond
-
 Escherichia coli a [DsbA protein] carrying a disulfide bond + a [DsbB protein] with reduced L-cysteine residues
-
 ?
1.8.5.9 a [DsbA protein] with reduced L-cysteine residues + ubiquinone overall reaction Escherichia coli a [DsbA protein] carrying a disulfide bond + ubiquinol
-
 ?
1.8.5.9 a [DsbB protein] with reduced L-cysteine residues + ubiquinone
-
 Escherichia coli a [DsbB protein] carrying a disulfide bond + ubiquinol
-
 ?
1.8.5.9 additional information the enzyme gains the ability to oxidize its specific substrate, DsbA protein, having very high redox potential, by undergoing a DsbA-induced rearrangement of cysteine residues. One of the enzyme cysteines that are now reduced then interacts with ubiquinone to form a charge transfer complex, leading to the regeneration of a disulfide at the enzyme active site Escherichia coli ?
-
-

Synonyms

EC Number Synonyms Comment Organism
1.8.5.9 DsbB
-
 Escherichia coli