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Literature summary extracted from

  • Paiardini, A.; Tramonti, A.; Schirch, D.; Guiducci, G.; di Salvo, M.L.; Fiascarelli, A.; Giorgi, A.; Maras, B.; Cutruzzola, F.; Contestabile, R.
    Differential 3-bromopyruvate inhibition of cytosolic and mitochondrial human serine hydroxymethyltransferase isoforms, key enzymes in cancer metabolic reprogramming (2016), Biochim. Biophys. Acta, 1864, 1506-1517 .
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.1.2.1 A206C the mutation yields an enzyme that forms a 3-bromopyruvate-enzyme complex and is completely inactivated Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.2.1 3-Bromopyruvate isoform SHMT1 is completely inhibited by 3-bromopyruvate; isoform SHMT2 retains a significant fraction of activity with 3-bromopyruvate Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.2.1 cytosol isoform SHMT1 Homo sapiens 5829
-
2.1.2.1 mitochondrion isoform SHMT2 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.2.1 5,10-methylenetetrahydrofolate + glycine + H2O Homo sapiens
-
 tetrahydrofolate + L-serine
-
 r
2.1.2.1 tetrahydrofolate + L-serine Homo sapiens
-
 5,10-methylenetetrahydrofolate + glycine + H2O
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.1.2.1 Homo sapiens P34896
-
-
2.1.2.1 Homo sapiens P34897
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.2.1 5,10-methylenetetrahydrofolate + glycine + H2O
-
 Homo sapiens tetrahydrofolate + L-serine
-
 r
2.1.2.1 tetrahydrofolate + L-serine
-
 Homo sapiens 5,10-methylenetetrahydrofolate + glycine + H2O
-
 r

Synonyms

EC Number Synonyms Comment Organism
2.1.2.1 serine hydroxymethyltransferase
-
 Homo sapiens
2.1.2.1 SHMT1 isoform Homo sapiens
2.1.2.1 SHMT2 isoform Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.2.1 pyridoxal 5'-phosphate
-
 Homo sapiens