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Literature summary extracted from

  • James, A.W.; Gowsalya, R.; Nachiappan, V.
    Dolichyl pyrophosphate phosphatase-mediated N-glycosylation defect dysregulates lipid homeostasis in Saccharomyces cerevisiae (2016), Biochim. Biophys. Acta, 1861, 1705-1718 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.1.43 dolichyl diphosphate + H2O Saccharomyces cerevisiae
-
 dolichyl phosphate + phosphate
-
 ?
3.6.1.43 dolichyl diphosphate + H2O Saccharomyces cerevisiae BY4741
-
 dolichyl phosphate + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.43 Saccharomyces cerevisiae
-
-
-
3.6.1.43 Saccharomyces cerevisiae BY4741
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.43 dolichyl diphosphate + H2O
-
 Saccharomyces cerevisiae dolichyl phosphate + phosphate
-
 ?
3.6.1.43 dolichyl diphosphate + H2O
-
 Saccharomyces cerevisiae BY4741 dolichyl phosphate + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.6.1.43 CAX4
-
 Saccharomyces cerevisiae
3.6.1.43 Dol-PP phosphatase
-
 Saccharomyces cerevisiae
3.6.1.43 dolichyl pyrophosphate phosphatase
-
 Saccharomyces cerevisiae

General Information

EC Number General Information Comment Organism
3.6.1.43 malfunction in enzyme-deficient cells showing endoplasmic reticulum stress, membrane and growth defect, the N-glycosylation of the vacuolar carboxypeptidase is severely affected, and expression of the endoplasmic reticulum chaperone Kar2p is elevated, which results in unfolded protein response activation as an adaptive response Saccharomyces cerevisiae
3.6.1.43 metabolism the enzyme is essential for phospholipid homeostasis Saccharomyces cerevisiae
3.6.1.43 physiological function the enzyme regulates membrane biogenesis by coordinating lipid homeostasis with protein quality control Saccharomyces cerevisiae