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Literature summary extracted from

  • Mullen, T.D.; Hannun, Y.A.; Obeid, L.M.
    Ceramide synthases at the centre of sphingolipid metabolism and biology (2012), Biochem. J., 441, 789-802 .
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.299 0.0025
-
 dihydrosphingosine pH and temperature not specified in the publication Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.299 endoplasmic reticulum
-
 Homo sapiens 5783
-
2.3.1.299 Golgi apparatus
-
 Homo sapiens 5794
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.299 oleoyl-CoA + sphingolipid Mus musculus
-
 N-(oleoyl)-sphingolipid + CoA
-
 ?
2.3.1.299 stearoyl-CoA + a sphingoid base Mus musculus
-
 an N-(stearoyl)-sphingoid base + CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.299 Homo sapiens
-
-
-
2.3.1.299 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.299 brain
-
 Mus musculus
-
2.3.1.299 head and neck squamous cell carcinoma cell
-
 Homo sapiens
-
2.3.1.299 HEK-293 cell
-
 Homo sapiens
-
2.3.1.299 lymph node
-
 Mus musculus
-
2.3.1.299 skeletal muscle
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.299 arachidoyl-CoA + dihydrosphingosine
-
 Homo sapiens N-(arachidoyl)-dihydrosphingosine + CoA
-
 ?
2.3.1.299 oleoyl-CoA + dihydrosphingosine
-
 Homo sapiens N-(oleoyl)-dihydrosphingosine + CoA
-
 ?
2.3.1.299 oleoyl-CoA + sphingolipid
-
 Mus musculus N-(oleoyl)-sphingolipid + CoA
-
 ?
2.3.1.299 stearoyl-CoA + a sphingoid base
-
 Mus musculus an N-(stearoyl)-sphingoid base + CoA
-
 ?
2.3.1.299 stearoyl-CoA + dihydrosphingosine
-
 Homo sapiens N-(stearoyl)-dihydrosphingosine + CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.299 ceramide synthase 1
-
 Mus musculus
2.3.1.299 ceramide synthase 1
-
 Homo sapiens
2.3.1.299 CerS1
-
 Mus musculus
2.3.1.299 CerS1
-
 Homo sapiens
2.3.1.299 LASS1
-
 Mus musculus
2.3.1.299 LASS1
-
 Homo sapiens
2.3.1.299 UOG1
-
 Mus musculus
2.3.1.299 UOG1
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.3.1.299 physiological function enzyme overexpression in HEK-293 cells increases sensitivity to the chemotherapeutic agents cisplatin, carboplatin, doxorubicin and vincristine. The enzyme is a negative regulator of head and neck squamous cell carcinoma cells Homo sapiens