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Literature summary extracted from

  • Young, L.C.; Hendzel, M.J.
    The oncogenic potential of Jumonji D2 (JMJD2/KDM4) histone demethylase overexpression (2013), Biochem. Cell Biol., 91, 369-377 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.11.66 additional information Mus musculus isoform KDM4D does not use [histone H3]-N6,N6,N6-trimethyl-L-lysine36 as substrate. All KDM4 proteins show no activity with [histone H3]-N6,N6-dimethyl-L-lysine36 ?
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1.14.11.66 [histone H3]-N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2 Mus musculus
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 [histone H3]-N6,N6-dimethyl-L-lysine36 + succinate + formaldehyde + CO2
-
 ?
1.14.11.66 [histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2 Mus musculus preferred target for all KDM4 proteins, in general exhibiting 4fold preference for [histone H3]-N6,N6,N6-trimethyl-L-lysine9 over [histone H3]-N6,N6,N6-trimethyl-L-lysine36. The preference for [histone H3]-N6,N6,N6-trimethyl-L-lysine9 over [histone H3]-N6,N6-dimethyl-L-lysine9 is more modest form KDM4A (less than 3fold), KDM4B (less than 1.5fold), and KDM4D (less than 2.5fold), while the preference for KDM4C is nearly equivalent [histone H3]-N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2
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 ?
1.14.11.66 [histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 Mus musculus
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 [histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
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 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.66 Mus musculus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.66 additional information isoform KDM4D does not use [histone H3]-N6,N6,N6-trimethyl-L-lysine36 as substrate. All KDM4 proteins show no activity with [histone H3]-N6,N6-dimethyl-L-lysine36 Mus musculus ?
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-
1.14.11.66 [histone H3]-N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2
-
 Mus musculus [histone H3]-N6,N6-dimethyl-L-lysine36 + succinate + formaldehyde + CO2
-
 ?
1.14.11.66 [histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2 preferred target for all KDM4 proteins, in general exhibiting 4fold preference for [histone H3]-N6,N6,N6-trimethyl-L-lysine9 over [histone H3]-N6,N6,N6-trimethyl-L-lysine36. The preference for [histone H3]-N6,N6,N6-trimethyl-L-lysine9 over [histone H3]-N6,N6-dimethyl-L-lysine9 is more modest form KDM4A (less than 3fold), KDM4B (less than 1.5fold), and KDM4D (less than 2.5fold), while the preference for KDM4C is nearly equivalent Mus musculus [histone H3]-N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?
1.14.11.66 [histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2
-
 Mus musculus [histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.11.66 JMJD2 Jumonji D2, gene name Mus musculus
1.14.11.66 KDM4
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 Mus musculus
1.14.11.66 KDM4A isoform Mus musculus
1.14.11.66 KDM4B isoform Mus musculus
1.14.11.66 Kdm4c isoform Mus musculus
1.14.11.66 KDM4D isoform Mus musculus

Expression

EC Number Organism Comment Expression
1.14.11.66 Mus musculus the enzyme is overexpressed in many cancer types up

General Information

EC Number General Information Comment Organism
1.14.11.66 physiological function enzyme overexpression contributes to the maintenance of a pluripotent state and induces numerous oncogenic effects. KDM4 proteins are a component of the cellular response to postreplicative and exogenous DNA damage Mus musculus