Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Chatterjee, S.B.; Hou, J.; Bandaru, V.V.R.; Pezhouh, M.K.; Syed Rifat Mannan, A.A.; Sharma, R.
    Lactosylceramide synthase beta-1,4-GalT-V A novel target for the diagnosis and therapy of human colorectal cancer (2019), Biochem. Biophys. Res. Commun., 508, 380-386 .
    View publication on PubMed

Application

EC Number Application Comment Organism
2.4.1.90 medicine the enzyme serves as a diagnostic and therapeutic biomarker for the progression of human colorectal cancer Homo sapiens
2.4.1.274 medicine B4GALT5 gene/protein expression is specifically increased in human colorectal cancer tumors, with a concomitant increase in its enzymatic activity, and product lactosylceramide, and increased dihydrosphingolipid metabolites. Inhibition of glycosphingolipid synthesis by the synthetic ceramide analog, D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol, concurrently inhibits colorectal cancer cell proliferation, as well as B4GALT5 mass and several glycosphingolipid levels Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.90 D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol potent inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.90 UDP-alpha-D-galactose + N-acetyl-D-glucosamine Homo sapiens
-
 UDP + N-acetyllactosamine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.90 Homo sapiens
-
-
-
2.4.1.274 Homo sapiens O43286
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.90 colorectal cancer cell
-
 Homo sapiens
-
2.4.1.90 HCT-116 cell
-
 Homo sapiens
-
2.4.1.274 HCT-116 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.90 UDP-alpha-D-galactose + N-acetyl-D-glucosamine
-
 Homo sapiens UDP + N-acetyllactosamine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.90 B4GalT5
-
 Homo sapiens
2.4.1.90 beta-1,4-galactosyltransferase-V
-
 Homo sapiens
2.4.1.90 beta-1,4-GalT-V
-
 Homo sapiens
2.4.1.90 lactosylceramide synthase
-
 Homo sapiens
2.4.1.90 UDP-Gal:betaGlcNAc beta-1,4-galactosyltransferase, polypeptide 5
-
 Homo sapiens
2.4.1.274 B4GalT5
-
 Homo sapiens
2.4.1.274 beta-1,4-GalT-V
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.4.1.90 Homo sapiens enzyme gene/protein expression is specifically increased in human colorectal cancer compared to visibly normal tissue up
2.4.1.274 Homo sapiens B4GALT5 gene/protein expression is specifically increased in human colorectal cancer up