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Literature summary extracted from

  • Swaminathan, S.; Birudukota, S.; Thakur, M.K.; Parveen, R.; Kandan, S.; Juluri, S.; Shaik, S.; Anand, N.N.; Burri, R.R.; Kristam, R.; Hallur, M.S.; Rajagopal, S.; Schreuder, H.; Langer, T.; Rudolph, C.; Ruf, S.; Dhakshinamoorthy, S.; Gosu, R.; Kannt, A.
    Crystal structures of monkey and mouse nicotinamide N-methyltransferase (NNMT) bound with end product, 1-methyl nicotinamide (2017), Biochem. Biophys. Res. Commun., 491, 416-422 .
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.1.1.1 in complex with product, 1-methyl nicotinamide, and demethylated cofactor, S-adenosyl-homocysteine, to 1.88 A resolution. 1-methyl nicotinamide binds to the active site and it would be trapped in the active site due to the formation of the bridge between the pole and long C-terminal loop Mus musculus
2.1.1.1 in complex with product, 1-methyl nicotinamide, and demethylated cofactor, S-adenosyl-homocysteine, to 1.88 A resolution. 1-methyl nicotinamide binds to the active site and it would be trapped in the active site due to the formation of the bridge between the pole and long C-terminal loop Macaca mulatta

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.1 1-methyl nicotinamide feedback inhibitor Macaca mulatta
2.1.1.1 1-methyl nicotinamide feedback inhibitor Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.1 Macaca mulatta F7ERX8
-
-
2.1.1.1 Mus musculus O55239
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.1 S-adenosyl-L-methionine + nicotinamide
-
 Mus musculus S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
 ?
2.1.1.1 S-adenosyl-L-methionine + nicotinamide
-
 Macaca mulatta S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
 ?