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Literature summary extracted from

  • Li, J.; Huang, Y.; Hou, Y.; Li, X.; Cao, H.; Cui, Z.
    Novel gene clusters and metabolic pathway involved in 3,5,6-trichloro-2-pyridinol degradation by Ralstonia sp. strain T6 (2013), Appl. Environ. Microbiol., 79, 7445-7453 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.14.172 expressed in Escherichia coli DH10B cells Ralstonia sp. T6

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.172 3,5,6-trichloropyridin-2-ol + FADH2 + O2 Ralstonia sp. T6
-
 3,6-dichloropyridine-2,5-dione + Cl- + FAD + H2O
-
 ?
1.14.14.172 3,6-dichloropyridine-2,5-diol + FADH2 + O2 Ralstonia sp. T6
-
 6-chloro-3-hydroxypyridine-2,5-dione + Cl- + FAD + H2O
-
 ?
1.14.14.172 6-chloropyridine-2,3,5-triol + FADH2 + O2 Ralstonia sp. T6
-
 3,6-dihydroxypyridine-2,5-dione + Cl- + FAD + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.172 Ralstonia sp. T6 L7VFL7
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.172 3,5,6-trichloropyridin-2-ol + FADH2 + O2
-
 Ralstonia sp. T6 3,6-dichloropyridine-2,5-dione + Cl- + FAD + H2O
-
 ?
1.14.14.172 3,6-dichloropyridine-2,5-diol + FADH2 + O2
-
 Ralstonia sp. T6 6-chloro-3-hydroxypyridine-2,5-dione + Cl- + FAD + H2O
-
 ?
1.14.14.172 6-chloropyridine-2,3,5-triol + FADH2 + O2
-
 Ralstonia sp. T6 3,6-dihydroxypyridine-2,5-dione + Cl- + FAD + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.172 tcpA
-
 Ralstonia sp. T6

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.172 FADH2 the enzyme needs flavin reductase TcpX to supply FADH2 when transforming 3,5,6-trichloropyridin-2-ol Ralstonia sp. T6

General Information

EC Number General Information Comment Organism
1.14.14.172 malfunction an enzyme gene disruption mutant is not able to degrade 3,5,6-trichloropyridin-2-ol but 3,6-dihydroxypyridine-2,5-dione Ralstonia sp. T6
1.14.14.172 metabolism key enzyme in the initial step of 3,5,6-trichloropyridin-2-ol degradation Ralstonia sp. T6