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Literature summary extracted from

  • Separovic, D.; Breen, P.; Joseph, N.; Bielawski, J.; Pierce, J.S.; VAN Buren, E.; Gudz, T.I.
    siRNA-mediated down-regulation of ceramide synthase 1 leads to apoptotic resistance in human head and neck squamous carcinoma cells after photodynamic therapy (2012), Anticancer Res., 32, 2479-2485 .
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.3.1.299 medicine the enzyme is a molecular target for controlling resistance to photodynamic therapy Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.299 stearoyl-CoA + a sphingoid base Homo sapiens
-
 an N-(stearoyl)-sphingoid base + CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.299 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.299 head and neck squamous cell carcinoma cell
-
 Homo sapiens
-
2.3.1.299 UM-SCC-22A cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.299 stearoyl-CoA + a sphingoid base
-
 Homo sapiens an N-(stearoyl)-sphingoid base + CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.299 ceramide synthase 1
-
 Homo sapiens
2.3.1.299 CerS1
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.3.1.299 malfunction enzyme knockdown leads to inhibition of photodynamic therapy-induced caspase 3-like activation, of apoptosis and cell death. Enzyme knockdown is associated with global and selective decreases in ceramides and dihydroceramides, in particular C18-, C18:1- and C20-ceramide post-photodynamic therapy Homo sapiens
2.3.1.299 physiological function the enzyme regulates apoptotic resistance to photodynamic therapy for cancer treatment Homo sapiens