Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Qi, J.; Lang, W.; Connelly, M.A.; Du, F.; Liang, Y.; Caldwell, G.W.; Martin, T.; Hansen, M.K.; Kuo, G.H.; Gaul, M.D.; Pocai, A.; Lee, S.
    Metabolic tracing of monoacylglycerol acyltransferase-2 activity in vitro and in vivo (2017), Anal. Biochem., 524, 68-75 .
    View publication on PubMed

Application

EC Number Application Comment Organism
2.3.1.22 analysis development of LC/ESI/MS/MS-based fat absorption assay using 1-oleoyl-glycerol-d5 and U13C-triglyceride to assess the ability of MGAT2 inhibitors to inhibit fat absorption in CD1 mice by a meal tolerance test Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.22 expression in HEK-293 cell Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.22 2-(benzylsulfanyl)-6-[6-[4-(4-fluorophenyl)piperazin-1-yl]pyrimidin-4-yl]-3-phenyl-3,4,5,6,7,8-hexahydropyrido[4,3-d]pyrimidine blocks MGAT2-mediated activity in vitro and in vivo Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.22 Homo sapiens Q3SYC2
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.22 acyl-CoA + 2-oleoylglycerol deuterated substrate 2-oleoylglycerol-d5 Homo sapiens CoA + 1-acyl-2-oleoylglycerol
-
 ?

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.3.1.22 0.000075
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 2-(benzylsulfanyl)-6-[6-[4-(4-fluorophenyl)piperazin-1-yl]pyrimidin-4-yl]-3-phenyl-3,4,5,6,7,8-hexahydropyrido[4,3-d]pyrimidine