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Literature summary extracted from

  • Iwata, H.; Kobayashi, Y.; Mizushima, D.; Watanabe, T.; Ogihara, J.; Kasumi, T.
    Complementary function of two transketolase isoforms from Moniliella megachiliensis in relation to stress response (2017), AMB Express, 7, 45 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.2.1.1 expressed in Saccharomyces cerevisiae BY4741 DELTAtkl1 mutant cells Moniliella megachiliensis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.2.1.1 sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate Moniliella megachiliensis
-
 D-ribose 5-phosphate + D-xylulose 5-phosphate
-
 ?
2.2.1.1 sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate Moniliella megachiliensis SN-124A
-
 D-ribose 5-phosphate + D-xylulose 5-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.2.1.1 Moniliella megachiliensis A0A1L7NSX5
-
-
2.2.1.1 Moniliella megachiliensis A0A1L7NSY2
-
-
2.2.1.1 Moniliella megachiliensis SN-124A A0A1L7NSX5
-
-
2.2.1.1 Moniliella megachiliensis SN-124A A0A1L7NSY2
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.2.1.1 sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate
-
 Moniliella megachiliensis D-ribose 5-phosphate + D-xylulose 5-phosphate
-
 ?
2.2.1.1 sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate
-
 Moniliella megachiliensis SN-124A D-ribose 5-phosphate + D-xylulose 5-phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.2.1.1 ? x * 70800, isoform TKL1, calculated from amino acid sequence Moniliella megachiliensis
2.2.1.1 ? x * 70800, isoform TKL2, calculated from amino acid sequence Moniliella megachiliensis

Synonyms

EC Number Synonyms Comment Organism
2.2.1.1 TKL1 isoform Moniliella megachiliensis
2.2.1.1 Tkl2 isoform Moniliella megachiliensis

Expression

EC Number Organism Comment Expression
2.2.1.1 Moniliella megachiliensis after short-term oxidative stress (0.15 mM menadione), isoform TKL1 expression remains low down
2.2.1.1 Moniliella megachiliensis in response to short-term osmotic stress (20% glucose or 1.2 M NaCl), isoform TKL2 expression shows no significant change additional information
2.2.1.1 Moniliella megachiliensis in response to short-term osmotic stress (20% glucose or 1.2 M NaCl), isoform TKL1 expression increases rapidly through the first 40 min before subsequently decreasing gradually. Long-term osmotic stress (20% glucose) yields increased expression of isoform TLK1 starting at 12 h and continuing through 72 h up
2.2.1.1 Moniliella megachiliensis short-term oxidative stress (0.15 mM menadione) induces considerable increase in isoform TKL2. Long-term osmotic stress (20% glucose) yields increased expression of isoform TLK2 starting at 12 h and continuing through 72 h up

General Information

EC Number General Information Comment Organism
2.2.1.1 physiological function isoform TKL1 is responsible primarily for the response to osmotic stress Moniliella megachiliensis
2.2.1.1 physiological function isoform TKL2 is responsible primarily for the response to oxidative stress Moniliella megachiliensis