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Literature summary extracted from

  • Turijan-Espinoza, E.; Salazar-Gonzalez, R.A.; Uresti-Rivera, E.E.; Hernandez-Hernandez, G.E.; Ortega-Juarez, M.; Milan, R.; Portales-Perez, D.
    A pilot study of the modulation of sirtuins on arylamine N-acetyltransferase 1 and 2 enzymatic activity (2018), Acta Pharm. Sin. B, 8, 188-199 .
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.5 additional information the activity of NAT1 in cell culture does not change when cells are stimulated with different concentrations of sirtuin agonist resveratrol, compared to cells in culture medium. NAT2 metabolizing capacity increases significantly when sirtuins are inhibited with nicotinamide Homo sapiens
2.3.1.5 additional information the activity of NAT1 in cell culture does not change when cells are stimulated with different concentrations of sirtuin agonist resveratrol, compared to cells in culture medium. No effect on NAT1 activity is observed when sirtuins are inhibited with different concentrations of nicotinamide for 24 h Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.5 additional information the activity of NAT1 in cell culture does not change when cells are stimulated with different concentrations of sirtuin agonist resveratrol; the activity of NAT1 in cell culture does not change when cells are stimulated with different concentrations of sirtuin agonist resveratrol, compared to cells in culture medium. No effect on NAT1 activity is observed when sirtuins are inhibited with different concentrations of nicotinamide for 24 h Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.5 cytosol
-
 Homo sapiens 5829
-

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.5 Homo sapiens P11245 isoform NAT2
-
2.3.1.5 Homo sapiens P18440
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.5 HeLa cell
-
 Homo sapiens
-
2.3.1.5 lymphocyte
-
 Homo sapiens
-
2.3.1.5 peripheral blood mononuclear cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.5 acetyl-CoA + 4-aminobenzoate
-
 Homo sapiens CoA + N-acetyl-4-aminobenzoate
-
 ?
2.3.1.5 acetyl-CoA + isoniazid
-
 Homo sapiens CoA + N-acetylisoniazid
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.5 NAT2
-
 Homo sapiens