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Literature summary extracted from

  • Digianantonio, K.M.; Korolev, M.; Hecht, M.H.
    A non-natural protein rescues cells deleted for a key enzyme in central metabolism (2017), ACS Synth. Biol., 6, 694-700 .
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
2.3.3.5 Escherichia coli P31660
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.3.5 propanoyl-CoA + H2O + oxaloacetate
-
 Escherichia coli (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.3.5 PrpC
-
 Escherichia coli

Expression

EC Number Organism Comment Expression
2.3.3.5 Escherichia coli the de novo protein SynGltA stimulates the prp operon. SynGltA allows cells to recover from a defect in central carbon and energy metabolism by altering the regulation of an alternative metabolic pathway. Specifically, SynGltA dramatically enhances the expression of prpC, a gene encoding methylcitrate synthase in the propionate degradation pathway. This endogenous protein has promiscuous catalytic activity, which when overexpressed, compensates for the deletion of citrate synthase up

General Information

EC Number General Information Comment Organism
2.3.3.5 metabolism the enzyme is involved in the propionate degradation pathway Escherichia coli