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Literature summary extracted from

  • Jenkins, M.H.; Alrowaished, S.S.; Goody, M.F.; Crawford, B.D.; Henry, C.A.
    Laminin and matrix metalloproteinase 11 regulate fibronectin levels in the zebrafish myotendinous junction (2016), Skeletal Muscle, 6, 18 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.B3 stable recombinant overexpresison of GFP-tagged enzyme in zebrafish Danio rerio

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.B3 extracellular
-
 Danio rerio
-
-
3.4.24.B3 extracellular matrix
-
 Danio rerio 31012
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.B3 Zn2+ a zinc-dependent endopeptidase Danio rerio

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.B3 Danio rerio
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.B3 embryo
-
 Danio rerio
-
3.4.24.B3 skeletal muscle localization to the myotendinous junction (MTJ), laminin is necessary to recruit/retain Mmp11 at the MTJ. Mmp11 is strongly expressed at the MTJ in zebrafish at 2 days post fertilization. Mmp11 expression throughout primary muscle development Danio rerio
-

Synonyms

EC Number Synonyms Comment Organism
3.4.24.B3 matrix metalloproteinase 11
-
 Danio rerio
3.4.24.B3 MMP11
-
 Danio rerio
3.4.24.B3 stromelysin-3
-
 Danio rerio

General Information

EC Number General Information Comment Organism
3.4.24.B3 physiological function the enzyme is involved in skeletal muscle development in zebrafish, morphogenesis of the myotendinous junction (MTJ), overview. Mmp11 localization to the MTJ is regulated by laminin. Laminin polymerization indirectly promotes fibronectin (Fn) downregulation at the MTJ, via a matrix metalloproteinase 11 (Mmp11)-dependent mechanism. Laminin deposition and organization is required for localization of Mmp11 to the MTJ, where Mmp11 is both necessary and sufficient for Fn downregulation in vivo. Furthermore, reduction of residual Mmp11 in laminin mutants promotes a Fn-rich MTJ that partially rescues skeletal muscle architecture. Mmp11 is necessary and sufficient for fibronectin downregulation Danio rerio