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Literature summary extracted from

  • Gallego-Garcia, A.; Monera-Girona, A.J.; Pajares-Martinez, E.; Bastida-Martinez, E.; Perez-Castano, R.; Iniesta, A.A.; Fontes, M.; Padmanabhan, S.; Elias-Arnanz, M.
    A bacterial light response reveals an orphan desaturase for human plasmalogen synthesis (2019), Science, 366, 128-132 .
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.14.19.77 H103A inactive Myxococcus xanthus
1.14.19.77 H104A inactive Myxococcus xanthus
1.14.19.77 H113A inactive Myxococcus xanthus
1.14.19.77 H120A inactive Homo sapiens
1.14.19.77 H121A inactive Homo sapiens
1.14.19.77 H130A inactive Homo sapiens
1.14.19.77 H164A inactive Myxococcus xanthus
1.14.19.77 H168A inactive Myxococcus xanthus
1.14.19.77 H183A the mutant shows enzymatic activity Myxococcus xanthus
1.14.19.77 H186A inactive Homo sapiens
1.14.19.77 H190A inactive Homo sapiens
1.14.19.77 H190A the mutant shows enzymatic activity Myxococcus xanthus
1.14.19.77 H191A inactive Myxococcus xanthus
1.14.19.77 H194A inactive Myxococcus xanthus
1.14.19.77 H195A inactive Myxococcus xanthus
1.14.19.77 H206A the mutant shows enzymatic activity Homo sapiens
1.14.19.77 H213A the mutant shows enzymatic activity Homo sapiens
1.14.19.77 H214A the mutant shows weak enzymatic activity Homo sapiens
1.14.19.77 H217A inactive Homo sapiens
1.14.19.77 H218A inactive Homo sapiens
1.14.19.77 H218A the mutant shows enzymatic activity Myxococcus xanthus
1.14.19.77 H222A the mutant shows enzymatic activity Homo sapiens
1.14.19.77 H78A inactive Myxococcus xanthus
1.14.19.77 H95A inactive Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.19.77 membrane
-
 Myxococcus xanthus 16020
-
1.14.19.77 membrane
-
 Homo sapiens 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.19.77 Iron contains two equivalents of iron Myxococcus xanthus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.19.77 alkyl ether plasmanylethanolamine + NADPH + O2 Myxococcus xanthus
-
 vinyl ether phosphatidylethanolamine + NADP+ + H2O
-
 ?
1.14.19.77 alkyl ether plasmanylethanolamine + NADPH + O2 Homo sapiens
-
 vinyl ether phosphatidylethanolamine + NADP+ + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.77 Homo sapiens A5PLL7
-
-
1.14.19.77 Myxococcus xanthus Q9AE87
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.19.77
-
 Myxococcus xanthus
1.14.19.77
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.19.77 HAP-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.77 alkyl ether plasmanylethanolamine + NADPH + O2
-
 Myxococcus xanthus vinyl ether phosphatidylethanolamine + NADP+ + H2O
-
 ?
1.14.19.77 alkyl ether plasmanylethanolamine + NADPH + O2
-
 Homo sapiens vinyl ether phosphatidylethanolamine + NADP+ + H2O
-
 ?
1.14.19.77 iso15:0-O-alkylglycerol-bis-trimethylsilyl ether + NADPH + O2
-
 Myxococcus xanthus iso15:0-dimethylacetal + NADP+ + H2O
-
 ?
1.14.19.77 iso16:0-O-alkylglycerol-bis-trimethylsilyl ether + NADPH + O2
-
 Homo sapiens iso16:0-dimethylacetal + NADP+ + H2O
-
 ?
1.14.19.77 iso18:0-O-alkylglycerol-bis-trimethylsilyl ether + NADPH + O2
-
 Homo sapiens iso18:0-dimethylacetal + NADP+ + H2O
-
 ?
1.14.19.77 iso18:1-O-alkylglycerol-bis-trimethylsilyl ether + NADPH + O2
-
 Homo sapiens iso18:1-dimethylacetal + NADP+ + H2O
-
 ?

Subunits

EC Number Subunits Comment Organism
1.14.19.77 ? x * 31000, SDS-PAGE Myxococcus xanthus
1.14.19.77 ? x * 31000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
1.14.19.77 CarF
-
 Myxococcus xanthus
1.14.19.77 TMEM189
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.14.19.77 physiological function the enzyme mediates light-induced carotenogenesis and and plasmalogen formation in Myxococcus xanthus Myxococcus xanthus