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Literature summary extracted from

  • Hachiya, R.; Shiihashi, T.; Shirakawa, I.; Iwasaki, Y.; Matsumura, Y.; Oishi, Y.; Nakayama, Y.; Miyamoto, Y.; Manabe, I.; Ochi, K.; Tanaka, M.; Goda, N.; Sakai, J.; Suganami, T.; Ogawa, Y.
    The H3K9 methyltransferase Setdb1 regulates TLR4-mediated inflammatory responses in macrophages (2016), Sci. Rep., 6, 28845 .
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.355 Mus musculus Q96KQ7
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2.1.1.366 Mus musculus O88974
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.355 macrophage
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 Mus musculus
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2.1.1.366 macrophage
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 Mus musculus
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Subunits

EC Number Subunits Comment Organism
2.1.1.355 ? x * 180000, SDS-PAGE Mus musculus

Synonyms

EC Number Synonyms Comment Organism
2.1.1.355 ESET
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 Mus musculus
2.1.1.355 H3K9 methyltransferase
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 Mus musculus
2.1.1.355 SETDB1
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 Mus musculus
2.1.1.366 SETDB1
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 Mus musculus

General Information

EC Number General Information Comment Organism
2.1.1.355 malfunction macrophage-specific enzyme-knockout mice exhibit higher serum interleukin-6 concentrations in response to lipopolysaccharide challenge and are more susceptible to endotoxin shock than wild type mice. Enzyme deficiency increases nuclear factor-kappaB p65 recruitment to the interleukin 6 promoter Mus musculus
2.1.1.355 physiological function the enzyme regulates toll-like receptor 4-mediated inflammatory responses in macrophages. The enzyme is an epigenetic regulator of proinflammatory cytokine expression in macrophages. The enzyme suppresses transcriptional activity of interleukin 6 promoter Mus musculus
2.1.1.366 physiological function Setdb1 in macrophages potently suppresses Toll-like receptor TLR4-mediated expression of proinflammatory cytokines including interleukin-6 through its methyltransferase activity. Setdb1-deficiency decreases the basal H3K9 methylation levels and augments TLR4-mediated NF-kappaB recruitment on the proximal promoter region of interleukin-6, thereby accelerating interleukin-6 promoter activity. Macrophage-specific Setdb1-knockout mice exhibit higher serum interleukin-6 concentrations in response to lipopolysaccharide challenge and are more susceptible to endotoxin shock than wild-type mice Mus musculus