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Literature summary extracted from

  • Nicolai, E.; Sinibaldi, F.; Sannino, G.; Lagana, G.; Basoli, F.; Licoccia, S.; Cozza, P.; Santucci, R.; Piro, M.C.
    Omega-3 and omega-6 fatty acids act as inhibitors of the matrix metalloproteinase-2 and matrix metalloproteinase-9 activity (2017), Protein J., 36, 278-285 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.35 gene MMP9, quantitative RT-PCR enzyme expression analysis Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.24 alpha-linolenic acid
-
 Homo sapiens
3.4.24.24 docosahexaenoic acid
-
 Homo sapiens
3.4.24.24 gamma-linolenic acid
-
 Homo sapiens
3.4.24.24 linoleic acid
-
 Homo sapiens
3.4.24.24 additional information omega-3 and omega-6 fatty acids act as inhibitors of matrix metalloproteinase-2 activity. Omega-3 and omega-6 fatty acids contribute to the structure and function of the phospholipid bilayers in cellular membranes and act as precursors of lipid-mediated signaling molecules Homo sapiens
3.4.24.24 oleic acid
-
 Homo sapiens
3.4.24.35 alpha-linolenic acid
-
 Homo sapiens
3.4.24.35 docosahexaenoic acid
-
 Homo sapiens
3.4.24.35 gamma-linolenic acid
-
 Homo sapiens
3.4.24.35 linoleic acid
-
 Homo sapiens
3.4.24.35 additional information omega-3 and omega-6 fatty acids act as inhibitors of matrix metalloproteinase-9 activity. Omega-3 and omega-6 fatty acids contribute to the structure and function of the phospholipid bilayers in cellular membranes and act as precursors of lipid-mediated signaling molecules Homo sapiens
3.4.24.35 oleic acid
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.24 extracellular the enzyme is secreted Homo sapiens
-
-
3.4.24.35 extracellular the enzyme is secreted Homo sapiens
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.24 Ca2+ required Homo sapiens
3.4.24.24 Zn2+ a zinc-dependent metalloprotease Homo sapiens
3.4.24.35 Ca2+ required Homo sapiens
3.4.24.35 Zn2+ a zinc-dependent metalloprotease Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.24 Homo sapiens P08253
-
-
3.4.24.35 Homo sapiens P14780
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.24.24 proteolytic modification activation of pro-MMP-2 with 1 mM APMA (p-aminophenylmercuric acetate) for 1 h at 37°C, in buffer containing 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM CaCl2, and 0.05% Brij L23 Homo sapiens
3.4.24.35 proteolytic modification activation of pro-MMP-2 with 1 mM APMA (p-aminophenylmercuric acetate) overnight at 37°C, in buffer containing 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM CaCl2, and 0.05% Brij L23 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.24 commercial preparation
-
 Homo sapiens
-
3.4.24.35 commercial preparation
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.24 Mca-KPLGL-(Dpa)-AR-NH2 + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.24 additional information enzyme activity is determined using human teeth as substrate Homo sapiens ?
-
 ?
3.4.24.35 Mca-KPLGL-(Dpa)-AR-NH2 + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.35 additional information enzyme activity is determined using human teeth as substrate Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.24 Matrix metalloproteinase 2
-
 Homo sapiens
3.4.24.24 MMP-2
-
 Homo sapiens
3.4.24.24 progelatinase
-
 Homo sapiens
3.4.24.35 Matrix metalloproteinase 9
-
 Homo sapiens
3.4.24.35 MMP-9
-
 Homo sapiens
3.4.24.35 progelatinase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.24.24 20 22 assay at Homo sapiens
3.4.24.35 20 22 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.24.24 7.5
-
 assay at Homo sapiens
3.4.24.35 7.5
-
 assay at Homo sapiens