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Literature summary extracted from

  • Li, J.; Dong, Y.; Lue, X.; Wang, L.; Peng, W.; Zhang, X.C.; Rao, Z.
    Crystal structures and biochemical studies of human lysophosphatidic acid phosphatase type 6 (2013), Protein Cell, 4, 548-561 .
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.1.3.106 structures in complex with malonate, L-(+)-tartrate and tris Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.1.3.106 L289W about 50% of wild-type activity with substrate myristoyl-sn-glycerol 3-phosphate Homo sapiens
3.1.3.106 S285W about 50% of wild-type activity with substrate myristoyl-sn-glycerol 3-phosphate Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.106 additional information Homo sapiens no substrate: glycerol 3-phosphate. Activity increases with the length of acyl chain to a peak value on 14:0-lysophosphatidic acid. Activity gradually decreases, when the substrate length is increased above the optimal 14:0-lysophosphatidic acid ?
-
 ?
3.1.3.106 myristoyl-sn-glycerol3-phosphate + H2O Homo sapiens best substrate myristoyl-sn-glycerol + phosphate
-
 ?
3.1.3.106 oleoyl-sn-glycerol 3-phosphate + H2O Homo sapiens about 2fold the activity of stearoyl-sn-glycerol 3-phosphate oleoyl-sn-glycerol + phosphate
-
 ?
3.1.3.106 palmitoyl-sn-glycerol 3-phosphate + H2O Homo sapiens
-
 palmitoyl-sn-glycerol + phosphate
-
 ?
3.1.3.106 stearoyl-sn-glycerol-3-phosphate + H2O Homo sapiens
-
 stearoyl-sn-glycerol + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.106 Homo sapiens Q9NPH0
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.106 additional information no substrate: glycerol 3-phosphate. Activity increases with the length of acyl chain to a peak value on 14:0-lysophosphatidic acid. Activity gradually decreases, when the substrate length is increased above the optimal 14:0-lysophosphatidic acid Homo sapiens ?
-
 ?
3.1.3.106 myristoyl-sn-glycerol3-phosphate + H2O best substrate Homo sapiens myristoyl-sn-glycerol + phosphate
-
 ?
3.1.3.106 oleoyl-sn-glycerol 3-phosphate + H2O about 2fold the activity of stearoyl-sn-glycerol 3-phosphate Homo sapiens oleoyl-sn-glycerol + phosphate
-
 ?
3.1.3.106 palmitoyl-sn-glycerol 3-phosphate + H2O
-
 Homo sapiens palmitoyl-sn-glycerol + phosphate
-
 ?
3.1.3.106 stearoyl-sn-glycerol-3-phosphate + H2O
-
 Homo sapiens stearoyl-sn-glycerol + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.106 Acp6
-
 Homo sapiens
3.1.3.106 lysophosphatidic acid phosphatase type 6
-
 Homo sapiens