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Literature summary extracted from

  • Song, E.S.; Jang, H.; Guo, H.F.; Juliano, M.A.; Juliano, L.; Morris, A.J.; Galperin, E.; Rodgers, D.W.; Hersh, L.B.
    Inositol phosphates and phosphoinositides activate insulin-degrading enzyme, while phosphoinositides also mediate binding to endosomes (2017), Proc. Natl. Acad. Sci. USA, 114, E2826-E2835 .
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.24.56 1-diphosphoinositol pentakisphosphate activates, maximal 79.7fold activation Rattus norvegicus
3.4.24.56 5-diphosphoinositol pentakisphosphate activates, maximal 94.7fold activation Rattus norvegicus
3.4.24.56 myoinositol 1,2,3,4,5,6-hexakisphosphate i.e. phytic acid, maximal 72fold activation Rattus norvegicus
3.4.24.56 myoinositol 1,2-bisphosphate activates, maximal 3.1fold activation Rattus norvegicus
3.4.24.56 myoinositol 1,3,4,5,6-pentakisphosphate activates, maximal 83.3fold activation Rattus norvegicus
3.4.24.56 myoinositol 1,3,4,5-tetrakisphosphate activates, maximal 58.6fold activation Rattus norvegicus
3.4.24.56 myoinositol 1,3,5-trisphosphate activates, maximal 12.9fold activation Rattus norvegicus
3.4.24.56 myoinositol 1,3-bisphosphate activates, maximal 6.1fold activation Rattus norvegicus
3.4.24.56 myoinositol 1,4,5-trisphosphate activates, maximal 30.6fold activation Rattus norvegicus
3.4.24.56 myoinositol 3-phosphate activates, maximal 6.2fold activation Rattus norvegicus
3.4.24.56 myoinositol 4,5-bisphosphate activates, maximal 13.8fold activation Rattus norvegicus

Protein Variants

EC Number Protein Variants Comment Organism
3.4.24.56 K898A/K899A/S901A variant with mutations in the polyanion-binding site shows reduced activation by myoinositol 1,4,5-trisphosphate and phytic acid Rattus norvegicus
3.4.24.56 Y609F activation by myoinositol 1,4,5-trisphosphate and phytic acid is decreased in the mutant enzyme Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.24.56 0.0111
-
 Abz-Gly-Gly-Leu-Arg-Lys-His-Gly-Gln-EDDnp 37°C, pH 7.4, without activator Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.56 endosome binding to phosphatdidylinositol phosphates facilitates its localization to endosomes Rattus norvegicus 5768
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.56 Rattus norvegicus P35559
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.56 Abz-Gly-Gly-Leu-Arg-Lys-His-Gly-Gln-EDDnp + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.24.56 amyloid beta-peptide(1-40) + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.24.56 angiotensin + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.24.56 beta-endorphin + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.24.56 bradykinin + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.24.56 dynorphin B9 + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.24.56 Glucagon + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.24.56 insulin + H2O
-
 Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.56 IDE
-
 Rattus norvegicus
3.4.24.56 Insulin-degrading enzyme
-
 Rattus norvegicus