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Literature summary extracted from

  • Das, U.; Chauleau, M.; Ordonez, H.; Shuman, S.
    Impact of DNA3pp5G capping on repair reactions at DNA 3 ends (2014), Proc. Natl. Acad. Sci. USA, 111, 11317-11322 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.6.1.72 expression in Escherichia coli Schizosaccharomyces pombe

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.1.72 [DNA]-3'-diphospho-5'-guanosine + H2O Schizosaccharomyces pombe
-
 [DNA]-3'-phosphate + GMP
-
 ?
3.6.1.72 [DNA]-3'-diphospho-5'-guanosine + H2O Schizosaccharomyces pombe 972
-
 [DNA]-3'-phosphate + GMP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.72 Schizosaccharomyces pombe O74859
-
-
3.6.1.72 Schizosaccharomyces pombe 972 O74859
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.72 [DNA]-3'-diphospho-5'-guanosine + H2O
-
 Schizosaccharomyces pombe [DNA]-3'-phosphate + GMP
-
 ?
3.6.1.72 [DNA]-3'-diphospho-5'-guanosine + H2O
-
 Schizosaccharomyces pombe 972 [DNA]-3'-phosphate + GMP
-
 ?

General Information

EC Number General Information Comment Organism
3.6.1.72 physiological function aprataxin is highly effective as a DNA 3' decapping enzyme, converting DNAppG to DNA3'p and GMP. The biochemical impact of DNA capping is to prevent resection and healing of a 3'-PO4 end, while permitting DNA synthesis, at the price of embedding a ribonucleotide and a diphosphate linkage in the repaired strand Schizosaccharomyces pombe