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Literature summary extracted from

  • Bhatt, A.; Fujiwara, N.; Bhatt, K.; Gurcha, S.S.; Kremer, L.; Chen, B.; Chan, J.; Porcelli, S.A.; Kobayashi, K.; Besra, G.S.; Jacobs, W.R.
    Deletion of kasB in Mycobacterium tuberculosis causes loss of acid-fastness and subclinical latent tuberculosis in immunocompetent mice (2007), Proc. Natl. Acad. Sci. USA, 104, 5157-5162 .
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.294 Mycobacterium tuberculosis
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Synonyms

EC Number Synonyms Comment Organism
2.3.1.294 beta-ketoacyl-acyl carrier protein synthase
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 Mycobacterium tuberculosis
2.3.1.294 KasB
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 Mycobacterium tuberculosis

General Information

EC Number General Information Comment Organism
2.3.1.294 malfunction enzyme gene deletion in Mycobacterium tuberculosis causes loss of acid-fastness and subclinical latent tuberculosis in immunocompetent mice. An additional outcome of enzyme gene deletion is the loss of ketomycolic acid trans-cyclopropanation and a drastic reduction in methoxymycolic acid trans-cyclopropanation. Although deletion of the enzyme also markedly alters the colony morphology and abolishes classic serpentine growth (cording), the most profound effect of enzyme gene deletion is the ability of the mutant strain to persist in infected immunocompetent mice for up to 600 days without causing disease or mortality Mycobacterium tuberculosis