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Literature summary extracted from

  • Mizutani, Y.; Sun, H.; Ohno, Y.; Sassa, T.; Wakashima, T.; Obara, M.; Yuyama, K.; Kihara, A.; Igarashi, Y.
    Cooperative synthesis of ultra long-chain fatty acid and ceramide during keratinocyte differentiation (2013), PLoS ONE, 8, e67317 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.298 expressed in HEK-293T cells Mus musculus
2.3.1.298 expressed in HEK-293T cells Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.298 an ultra-long-chain fatty acyl-CoA + a sphingoid base Mus musculus
-
 an ultra-long-chain ceramide + CoA
-
 ?
2.3.1.298 an ultra-long-chain fatty acyl-CoA + a sphingoid base Homo sapiens
-
 an ultra-long-chain ceramide + CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.298 Homo sapiens
-
-
-
2.3.1.298 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.298 epidermis
-
 Mus musculus
-
2.3.1.298 epidermis
-
 Homo sapiens
-
2.3.1.298 keratinocyte
-
 Mus musculus
-
2.3.1.298 keratinocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.298 an ultra-long-chain fatty acyl-CoA + a sphingoid base
-
 Mus musculus an ultra-long-chain ceramide + CoA
-
 ?
2.3.1.298 an ultra-long-chain fatty acyl-CoA + a sphingoid base
-
 Homo sapiens an ultra-long-chain ceramide + CoA
-
 ?
2.3.1.298 behenoyl-CoA + a sphingoid base
-
 Mus musculus behenoyl ceramide + CoA
-
 ?
2.3.1.298 behenoyl-CoA + a sphingoid base
-
 Homo sapiens behenoyl ceramide + CoA
-
 ?
2.3.1.298 hexacosanoyl-CoA + a sphingoid base
-
 Mus musculus hexacosanoyl ceramide + CoA
-
 ?
2.3.1.298 hexacosanoyl-CoA + a sphingoid base
-
 Homo sapiens hexacosanoyl ceramide + CoA
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.298 ? x * 35000, SDS-PAGE Mus musculus
2.3.1.298 ? x * 35000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.3.1.298 CerS3
-
 Mus musculus
2.3.1.298 CerS3
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.3.1.298 Mus musculus enzyme mRNA increases during keratinocyte differentiation up
2.3.1.298 Homo sapiens enzyme mRNA increases during keratinocyte differentiation up

General Information

EC Number General Information Comment Organism
2.3.1.298 malfunction enzyme knockdown causes a reduction in the elongase activities toward ultra-long-chain acyl-CoAs Mus musculus
2.3.1.298 malfunction enzyme knockdown causes a reduction in the elongase activities toward ultra-long-chain acyl-CoAs Homo sapiens
2.3.1.298 metabolism the enzyme positively regulates very-long chain and ultra-long-chain fatty acid synthesis in keratinocytes. The enzyme regulates activities of ELOVL1 and ELOVL4 in differentiated keratinocytes Mus musculus
2.3.1.298 metabolism the enzyme positively regulates very-long chain and ultra-long-chain fatty acid synthesis in keratinocytes. The enzyme regulates activities of ELOVL1 and ELOVL4 in differentiated keratinocytes Homo sapiens