Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Quesada, A.; Segarra, A.B.; Montoro-Molina, S.; de Gracia, M.D.; Osuna, A.; O'Valle, F.; Gomez-Guzman, M.; Vargas, F.; Wangensteen, R.
    Glutamyl aminopeptidase in microvesicular and exosomal fractions of urine is related with renal dysfunction in cisplatin-treated rats (2017), PLoS ONE, 12, e0175462 .
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.4.11.2 diagnostics determination of AlaAp content or its enzymatic activity in microvesicular and exosomal fractions of urine is an early and predictive biomarker of renal dysfunction in cisplatin-induced nephrotoxicity. Nephrotoxic effect of cisplatin over tubular epithelia can be assessed independently of creatinine status or diuresis, overview. It might also be a very useful marker in pathologies where evaluation of early tubular damage takes relevance Rattus norvegicus
3.4.11.7 diagnostics determination of GluAp content or its enzymatic activity in microvesicular and exosomal fractions of urine is an early and predictive biomarker of renal dysfunction in cisplatin-induced nephrotoxicity. Nephrotoxic effect of cisplatin over tubular epithelia can be assessed independently of creatinine status or diuresis, overview. It might also be a very useful marker in pathologies where evaluation of early tubular damage takes relevance Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.11.2 extracellular in microvesicular and exosomal fractions of urine Rattus norvegicus
-
-
3.4.11.7 extracellular in microvesicular and exosomal fractions of urine Rattus norvegicus
-
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.2 Rattus norvegicus P15684
-
-
3.4.11.2 Rattus norvegicus Wistar P15684
-
-
3.4.11.7 Rattus norvegicus P50123
-
-
3.4.11.7 Rattus norvegicus Wistar P50123
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.11.2 kidney
-
 Rattus norvegicus
-
3.4.11.2 urine in microvesicular and exosomal fractions Rattus norvegicus
-
3.4.11.7 kidney
-
 Rattus norvegicus
-
3.4.11.7 urine in microvesicular and exosomal fractions Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.2 L-alanyl-2-naphthylamide + H2O
-
 Rattus norvegicus L-alanine + 2-naphthylamine
-
 ?
3.4.11.2 L-alanyl-2-naphthylamide + H2O
-
 Rattus norvegicus Wistar L-alanine + 2-naphthylamine
-
 ?
3.4.11.7 L-glutamic acid gamma-2-naphthylamide + H2O
-
 Rattus norvegicus L-glutamate + 2-naphthylamide
-
 ?
3.4.11.7 L-glutamic acid gamma-2-naphthylamide + H2O
-
 Rattus norvegicus Wistar L-glutamate + 2-naphthylamide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.11.2 AlaAP
-
 Rattus norvegicus
3.4.11.2 alanyl aminopeptidase
-
 Rattus norvegicus
3.4.11.2 ENPEP
-
 Rattus norvegicus
3.4.11.7 ENPEP
-
 Rattus norvegicus
3.4.11.7 GluAP
-
 Rattus norvegicus
3.4.11.7 glutamyl aminopeptidase
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.11.2 37
-
 assay at Rattus norvegicus
3.4.11.7 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.11.2 8.7
-
 assay at Rattus norvegicus
3.4.11.7 8.7
-
 assay at Rattus norvegicus

Expression

EC Number Organism Comment Expression
3.4.11.2 Rattus norvegicus increase of AlaAp in microvesicular and exosomal fractions from cisplatin-treated rats up
3.4.11.7 Rattus norvegicus increase of GluAp in microvesicular and exosomal fractions from cisplatin-treated rats up

General Information

EC Number General Information Comment Organism
3.4.11.2 physiological function an early high increase in the excretion or activity of the enzyme in supernatant of urine from cisplatin-treated rats are correlated with the extent of renal damage Rattus norvegicus
3.4.11.7 physiological function an early high increase in the excretion or activity of the enzyme in supernatant of urine from cisplatin-treated rats are correlated with the extent of renal damage Rattus norvegicus