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Literature summary extracted from

  • Fajtova, P.; Stefanic, S.; Hradilek, M.; Dvorak, J.; Vondrasek, J.; Jilkova, A.; Ulrychova, L.; McKerrow, J.H.; Caffrey, C.R.; Mares, M.; Horn, M.
    Prolyl oligopeptidase from the blood fluke Schistosoma mansoni From functional analysis to anti-schistosomal inhibitors (2015), PLoS Negl. Trop. Dis., 9, e0003827 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.26 expressed in Escherichia coli BL21(DE3) cells Schistosoma mansoni

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.26 3,4-dichloroisocoumarin
-
 Homo sapiens
3.4.21.26 3,4-dichloroisocoumarin 77.3% inhibition at 0.1 mM Schistosoma mansoni
3.4.21.26 antipain
-
 Homo sapiens
3.4.21.26 antipain 32.4% inhibition at 0.02 mM Schistosoma mansoni
3.4.21.26 Aprotinin
-
 Homo sapiens
3.4.21.26 Aprotinin 1.4% inhibition at 0.05 mM Schistosoma mansoni
3.4.21.26 benzamidine
-
 Homo sapiens
3.4.21.26 benzamidine 3.7% inhibition at 0.01 mM Schistosoma mansoni
3.4.21.26 bestatin
-
 Homo sapiens
3.4.21.26 bestatin 2.3% inhibition at 0.001 mM Schistosoma mansoni
3.4.21.26 diisopropyl fluorophosphate
-
 Homo sapiens
3.4.21.26 diisopropyl fluorophosphate complete inhibition at 0.1 mM Schistosoma mansoni
3.4.21.26 E64
-
 Homo sapiens
3.4.21.26 E64 6.5% inhibition at 0.01 mM Schistosoma mansoni
3.4.21.26 EDTA
-
 Homo sapiens
3.4.21.26 EDTA 3.8% inhibition at 1 mM Schistosoma mansoni
3.4.21.26 leupeptin
-
 Homo sapiens
3.4.21.26 leupeptin 2.3% inhibition at 0.02 mM Schistosoma mansoni
3.4.21.26 N-p-tosyl-L-phenylalanine chloromethylketone 67.2% inhibition at 0.001 mM Schistosoma mansoni
3.4.21.26 N-p-tosyl-L-phenylalanine-chloromethylketone
-
 Homo sapiens
3.4.21.26 Nalpha-tosyl-L-lysine chloromethylketone 38.3% inhibition at 0.001 mM Schistosoma mansoni
3.4.21.26 Nalpha-tosyl-L-lysine-chloromethylketone
-
 Homo sapiens
3.4.21.26 Pefabloc SC
-
 Homo sapiens
3.4.21.26 Pefabloc SC 12% inhibition at 1 mM Schistosoma mansoni
3.4.21.26 pepstatin A
-
 Homo sapiens
3.4.21.26 pepstatin A 7.3% inhibition at 0.001 mM Schistosoma mansoni
3.4.21.26 phenylmethylsulfonyl fluoride
-
 Homo sapiens
3.4.21.26 phenylmethylsulfonyl fluoride 47.6% inhibition at 1 mM Schistosoma mansoni
3.4.21.26 Soybean trypsin inhibitor
-
 Homo sapiens
3.4.21.26 Soybean trypsin inhibitor 12.3% inhibition at 0.01 mM Schistosoma mansoni
3.4.21.26 SUAM 14746 i.e. 3-([4-[2-(E)-styrylphenoxy]butanoyl]-L-4-hydroxyprolyl)thiazolidine Homo sapiens
3.4.21.26 SUAM 14746 i.e. 3-([4-[2-(E)-styrylphenoxy]butanoyl]-L-4-hydroxyprolyl)thiazolidine Schistosoma mansoni
3.4.21.26 Y-29794 oxalate
-
 Homo sapiens
3.4.21.26 Y-29794 oxalate
-
 Schistosoma mansoni
3.4.21.26 Z-Ala-Pro-aldehyde
-
 Homo sapiens
3.4.21.26 Z-Ala-Pro-aldehyde
-
 Schistosoma mansoni
3.4.21.26 Z-Ala-Pro-chloromethylketone
-
 Homo sapiens
3.4.21.26 Z-Ala-Pro-chloromethylketone complete inhibition at 0.001 mM Schistosoma mansoni
3.4.21.26 Z-Arg-Pro-aldehyde
-
 Homo sapiens
3.4.21.26 Z-Arg-Pro-aldehyde
-
 Schistosoma mansoni
3.4.21.26 Z-Arg-Pro-chloromethylketone
-
 Homo sapiens
3.4.21.26 Z-Arg-Pro-chloromethylketone
-
 Schistosoma mansoni
3.4.21.26 Z-Gly-Pro-aldehyde
-
 Homo sapiens
3.4.21.26 Z-Gly-Pro-aldehyde
-
 Schistosoma mansoni
3.4.21.26 Z-Lys-Pro-aldehyde
-
 Homo sapiens
3.4.21.26 Z-Lys-Pro-aldehyde
-
 Schistosoma mansoni
3.4.21.26 Z-Pro
-
 Homo sapiens
3.4.21.26 Z-Pro 41.1% inhibition at 0.1 mM Schistosoma mansoni
3.4.21.26 Z-Pro-Pro
-
 Homo sapiens
3.4.21.26 Z-Pro-Pro 37.6% inhibition at 0.1 mM Schistosoma mansoni
3.4.21.26 Z-Pro-Pro-aldehyde
-
 Homo sapiens
3.4.21.26 Z-Pro-Pro-aldehyde complete inhibition at 0.001 mM Schistosoma mansoni
3.4.21.26 Z-Tyr-Pro-aldehyde
-
 Homo sapiens
3.4.21.26 Z-Tyr-Pro-aldehyde
-
 Schistosoma mansoni

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.26 Homo sapiens
-
-
-
3.4.21.26 Schistosoma mansoni W8GKU3 blood fluke
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.26 Hi-Trap column chromatography and Mono Q column chromatography Schistosoma mansoni

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.26 adult
-
 Schistosoma mansoni
-
3.4.21.26 cercaria
-
 Schistosoma mansoni
-
3.4.21.26 egg
-
 Schistosoma mansoni
-
3.4.21.26 integument
-
 Schistosoma mansoni
-
3.4.21.26 miracidium
-
 Schistosoma mansoni
-
3.4.21.26 additional information not observed in the gastrodermis, gut lumen and muscular tissues Schistosoma mansoni
-
3.4.21.26 parenchyma
-
 Schistosoma mansoni
-
3.4.21.26 sporocyst
-
 Schistosoma mansoni
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.26 Abz-Ala-Ala-Pro-4-nitrophenylalanine + H2O about 10% activity compared to Abz-Lys-Pro-4-nitrophenylalanine Homo sapiens Abz-Ala-Ala-Pro + 4-nitrophenylalanine
-
 ?
3.4.21.26 Abz-Ala-Ala-Pro-4-nitrophenylalanine + H2O about 50% activity compared to Abz-Lys-Pro-4-nitrophenylalanine Schistosoma mansoni Abz-Ala-Ala-Pro + 4-nitrophenylalanine
-
 ?
3.4.21.26 Abz-Ala-Pro-Ala-4-nitrophenylalanine + H2O about 10% activity compared to Abz-Lys-Pro-4-nitrophenylalanine Homo sapiens Abz-Ala-Pro + L-Ala-4-nitrophenylalanine
-
 ?
3.4.21.26 Abz-Ala-Pro-Ala-4-nitrophenylalanine + H2O about 27% activity compared to Abz-Lys-Pro-4-nitrophenylalanine Schistosoma mansoni Abz-Ala-Pro + L-Ala-4-nitrophenylalanine
-
 ?
3.4.21.26 Abz-Ala-Pro-Gly-4-nitrophenylalanine + H2O about 20% activity compared to Abz-Lys-Pro-4-nitrophenylalanine Homo sapiens Abz-Ala-Pro + Gly-4-nitrophenylalanine
-
 ?
3.4.21.26 Abz-Ala-Pro-Gly-4-nitrophenylalanine + H2O about 40% activity compared to Abz-Lys-Pro-4-nitrophenylalanine Schistosoma mansoni Abz-Ala-Pro + Gly-4-nitrophenylalanine
-
 ?
3.4.21.26 Abz-Gly-Gly-Pro-4-nitrophenylalanine + H2O about 2% activity compared to Abz-Lys-Pro-4-nitrophenylalanine Homo sapiens Abz-Gly-Gly-Pro + 4-nitrophenylalanine
-
 ?
3.4.21.26 Abz-Gly-Gly-Pro-4-nitrophenylalanine + H2O about 20% activity compared to Abz-Lys-Pro-4-nitrophenylalanine Schistosoma mansoni Abz-Gly-Gly-Pro + 4-nitrophenylalanine
-
 ?
3.4.21.26 Abz-Gly-Pro-4-nitrophenylalanine + H2O about 20% activity compared to Abz-Lys-Pro-4-nitrophenylalanine Schistosoma mansoni Abz-Gly-Pro + 4-nitrophenylalanine
-
 ?
3.4.21.26 Abz-Gly-Pro-4-nitrophenylalanine + H2O about 7% activity compared to Abz-Lys-Pro-4-nitrophenylalanine Homo sapiens Abz-Gly-Pro + 4-nitrophenylalanine
-
 ?
3.4.21.26 Abz-Lys-Pro-4-nitrophenylalanine + H2O 100% activity Homo sapiens Abz-Lys-Pro + 4-nitrophenylalanine
-
 ?
3.4.21.26 Abz-Lys-Pro-4-nitrophenylalanine + H2O 100% activity Schistosoma mansoni Abz-Lys-Pro + 4-nitrophenylalanine
-
 ?
3.4.21.26 alpha-melanocyte-stimulating hormone + H2O acetyl-SYSMEHFRWGKPV Schistosoma mansoni acetyl-SYSMEHFRWGKP + L-Val
-
 ?
3.4.21.26 angiotensin I + H2O DRVYIHPFHL Schistosoma mansoni DRVYIHP + FHL
-
 ?
3.4.21.26 angiotensin II + H2O DRVYIHPF Schistosoma mansoni DRVYIHP + L-Phe
-
 ?
3.4.21.26 bradykinin + H2O RPPGFSPFR Schistosoma mansoni RPP + GFSP + L-Phe-L-Arg
-
 ?
3.4.21.26 L-Lys-L-Pro-7-amido-4-methylcoumarin + H2O about 3% activity compared to Z-Gly-L-Pro-7-amido-4-methylcoumarin Schistosoma mansoni L-Lys-L-Pro + 7-amino-4-methylcoumarin
-
 ?
3.4.21.26 L-Lys-L-Pro-7-amido-4-methylcoumarin + H2O about 5% activity compared to Z-Gly-L-Pro-7-amido-4-methylcoumarin Homo sapiens L-Lys-L-Pro + 7-amino-4-methylcoumarin
-
 ?
3.4.21.26 luteinizing-hormone-releasing hormone + H2O pEHWSYGLRPG Schistosoma mansoni pEHWSYGLRP + Gly
-
 ?
3.4.21.26 additional information no activity with Abz-L-Pro-L-Pro-4-nitrophenylalanine, Abz-L-Pro-L-Pro-L-Ala-4-nitrophenylalanine, Gly-L-Pro-7-amido-4-methylcoumarin, and L-Pro-7-amido-4-methylcoumarin Homo sapiens ?
-
 ?
3.4.21.26 additional information no activity with Abz-L-Pro-L-Pro-4-nitrophenylalanine, Abz-L-Pro-L-Pro-L-Ala-4-nitrophenylalanine, Gly-L-Pro-7-amido-4-methylcoumarin, and L-Pro-7-amido-4-methylcoumarin Schistosoma mansoni ?
-
 ?
3.4.21.26 additional information no activity with human hemoglobin, human serum albumin, human collagen type I, and human collagen type IV Schistosoma mansoni ?
-
 ?
3.4.21.26 neurotensin + H2O pELYENKPRRPYIL Schistosoma mansoni pELYENKP + RRP + YIL
-
 ?
3.4.21.26 oxytocin + H2O CYIQNCPLG Schistosoma mansoni CYIQNCP + L-Leu-Gly
-
 ?
3.4.21.26 substance P + H2O RPKPQQFFGLM Schistosoma mansoni RPKP + QQFFGLM
-
 ?
3.4.21.26 succinyl-Gly-Pro-Leu-Gly-Pro-7-amido-4-methylcoumarin + H2O about 58% activity compared to Z-Gly-L-Pro-7-amido-4-methylcoumarin Homo sapiens succinyl-Gly-Pro-Leu-Gly-Pro + 7-amino-4-methylcoumarin
-
 ?
3.4.21.26 succinyl-Gly-Pro-Leu-Gly-Pro-7-amido-4-methylcoumarin + H2O about 65% activity compared to Z-Gly-L-Pro-7-amido-4-methylcoumarin Schistosoma mansoni succinyl-Gly-Pro-Leu-Gly-Pro + 7-amino-4-methylcoumarin
-
 ?
3.4.21.26 vassopresin + H2O CYFQNCPRG Schistosoma mansoni CYFQNCP + L-Arg-Gly
-
 ?
3.4.21.26 Z-Ala-Pro-7-amido-4-carbamoylmethylcoumarin + H2O about 60% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin Schistosoma mansoni Z-Ala-Pro + 7-amino-4-carbamoylmethylcoumarin
-
 ?
3.4.21.26 Z-Ala-Pro-7-amido-4-carbamoylmethylcoumarin + H2O about 90% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin Homo sapiens Z-Ala-Pro + 7-amino-4-carbamoylmethylcoumarin
-
 ?
3.4.21.26 Z-Arg-Pro-7-amido-4-carbamoylmethylcoumarin + H2O about 87% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin Homo sapiens Z-Arg-Pro + 7-amino-4-carbamoylmethylcoumarin
-
 ?
3.4.21.26 Z-Arg-Pro-7-amido-4-carbamoylmethylcoumarin + H2O about 90% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin Schistosoma mansoni Z-Arg-Pro + 7-amino-4-carbamoylmethylcoumarin
-
 ?
3.4.21.26 Z-Asn-Pro-7-amido-4-carbamoylmethylcoumarin + H2O about 30% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin Homo sapiens Z-Asn-Pro + 7-amino-4-carbamoylmethylcoumarin
-
 ?
3.4.21.26 Z-Asn-Pro-7-amido-4-carbamoylmethylcoumarin + H2O about 40% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin Schistosoma mansoni Z-Asn-Pro + 7-amino-4-carbamoylmethylcoumarin
-
 ?
3.4.21.26 Z-Asp-Pro-7-amido-4-carbamoylmethylcoumarin + H2O about 10% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin Schistosoma mansoni Z-Asp-Pro + 7-amino-4-carbamoylmethylcoumarin
-
 ?
3.4.21.26 Z-Asp-Pro-7-amido-4-carbamoylmethylcoumarin + H2O about 5% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin Homo sapiens Z-Asp-Pro + 7-amino-4-carbamoylmethylcoumarin
-
 ?
3.4.21.26 Z-Gln-Pro-7-amido-4-carbamoylmethylcoumarin + H2O about 38% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin Homo sapiens Z-Gln-Pro + 7-amino-4-carbamoylmethylcoumarin
-
 ?
3.4.21.26 Z-Gln-Pro-7-amido-4-carbamoylmethylcoumarin + H2O about 38% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin Schistosoma mansoni Z-Gln-Pro + 7-amino-4-carbamoylmethylcoumarin
-
 ?
3.4.21.26 Z-Glu-Pro-7-amido-4-carbamoylmethylcoumarin + H2O about 18% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin Homo sapiens Z-Glu-Pro + 7-amino-4-carbamoylmethylcoumarin
-
 ?
3.4.21.26 Z-Glu-Pro-7-amido-4-carbamoylmethylcoumarin + H2O about 20% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin Schistosoma mansoni Z-Glu-Pro + 7-amino-4-carbamoylmethylcoumarin
-
 ?
3.4.21.26 Z-Gly-L-Pro-7-amido-4-methylcoumarin + H2O 100% activity Schistosoma mansoni Z-Gly-L-Pro + 7-amino-4-methylcoumarin
-
 ?
3.4.21.26 Z-Gly-Pro-7-amido-4-carbamoylmethylcoumarin + H2O about 22% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin Homo sapiens Z-Gly-Pro + 7-amino-4-carbamoylmethylcoumarin
-
 ?
3.4.21.26 Z-Gly-Pro-7-amido-4-carbamoylmethylcoumarin + H2O about 70% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin Schistosoma mansoni Z-Gly-Pro + 7-amino-4-carbamoylmethylcoumarin
-
 ?
3.4.21.26 Z-His-Pro-7-amido-4-carbamoylmethylcoumarin + H2O about 58% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin Homo sapiens Z-His-Pro + 7-amino-4-carbamoylmethylcoumarin
-
 ?
3.4.21.26 Z-His-Pro-7-amido-4-carbamoylmethylcoumarin + H2O about 65% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin Schistosoma mansoni Z-His-Pro + 7-amino-4-carbamoylmethylcoumarin
-
 ?
3.4.21.26 Z-Ile-Pro-7-amido-4-carbamoylmethylcoumarin + H2O about 60% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin Schistosoma mansoni Z-Ile-Pro + 7-amino-4-carbamoylmethylcoumarin
-
 ?
3.4.21.26 Z-Ile-Pro-7-amido-4-carbamoylmethylcoumarin + H2O about 92% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin Homo sapiens Z-Ile-Pro + 7-amino-4-carbamoylmethylcoumarin
-
 ?
3.4.21.26 Z-Leu-Pro-7-amido-4-carbamoylmethylcoumarin + H2O about 50% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin Schistosoma mansoni Z-Leu-Pro + 7-amino-4-carbamoylmethylcoumarin
-
 ?
3.4.21.26 Z-Leu-Pro-7-amido-4-carbamoylmethylcoumarin + H2O about 70% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin Homo sapiens Z-Leu-Pro + 7-amino-4-carbamoylmethylcoumarin
-
 ?
3.4.21.26 Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin + H2O 100% activity Homo sapiens Z-Lys-Pro + 7-amino-4-carbamoylmethylcoumarin
-
 ?
3.4.21.26 Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin + H2O 100% activity Schistosoma mansoni Z-Lys-Pro + 7-amino-4-carbamoylmethylcoumarin
-
 ?
3.4.21.26 Z-Met-Pro-7-amido-4-carbamoylmethylcoumarin + H2O about 67% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin Schistosoma mansoni Z-Met-Pro + 7-amino-4-carbamoylmethylcoumarin
-
 ?
3.4.21.26 Z-Met-Pro-7-amido-4-carbamoylmethylcoumarin + H2O about 68% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin Homo sapiens Z-Met-Pro + 7-amino-4-carbamoylmethylcoumarin
-
 ?
3.4.21.26 Z-Phe-Pro-7-amido-4-carbamoylmethylcoumarin + H2O about 48% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin Homo sapiens Z-Phe-Pro + 7-amino-4-carbamoylmethylcoumarin
-
 ?
3.4.21.26 Z-Phe-Pro-7-amido-4-carbamoylmethylcoumarin + H2O about 65% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin Schistosoma mansoni Z-Phe-Pro + 7-amino-4-carbamoylmethylcoumarin
-
 ?
3.4.21.26 Z-Pro-Pro-7-amido-4-carbamoylmethylcoumarin + H2O about 3% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin Homo sapiens Z-Pro-Pro + 7-amino-4-carbamoylmethylcoumarin
-
 ?
3.4.21.26 Z-Pro-Pro-7-amido-4-carbamoylmethylcoumarin + H2O about 3% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin Schistosoma mansoni Z-Pro-Pro + 7-amino-4-carbamoylmethylcoumarin
-
 ?
3.4.21.26 Z-Ser-Pro-7-amido-4-carbamoylmethylcoumarin + H2O about 30% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin Homo sapiens Z-Ser-Pro + 7-amino-4-carbamoylmethylcoumarin
-
 ?
3.4.21.26 Z-Ser-Pro-7-amido-4-carbamoylmethylcoumarin + H2O about 60% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin Schistosoma mansoni Z-Ser-Pro + 7-amino-4-carbamoylmethylcoumarin
-
 ?
3.4.21.26 Z-Thr-Pro-7-amido-4-carbamoylmethylcoumarin + H2O about 50% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin Schistosoma mansoni Z-Thr-Pro + 7-amino-4-carbamoylmethylcoumarin
-
 ?
3.4.21.26 Z-Thr-Pro-7-amido-4-carbamoylmethylcoumarin + H2O about 75% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin Homo sapiens Z-Thr-Pro + 7-amino-4-carbamoylmethylcoumarin
-
 ?
3.4.21.26 Z-Trp-Pro-7-amido-4-carbamoylmethylcoumarin + H2O about 23% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin Homo sapiens Z-Trp-Pro + 7-amino-4-carbamoylmethylcoumarin
-
 ?
3.4.21.26 Z-Trp-Pro-7-amido-4-carbamoylmethylcoumarin + H2O about 30% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin Schistosoma mansoni Z-Trp-Pro + 7-amino-4-carbamoylmethylcoumarin
-
 ?
3.4.21.26 Z-Tyr-Pro-7-amido-4-carbamoylmethylcoumarin + H2O about 60% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin Homo sapiens Z-Tyr-Pro + 7-amino-4-carbamoylmethylcoumarin
-
 ?
3.4.21.26 Z-Tyr-Pro-7-amido-4-carbamoylmethylcoumarin + H2O about 70% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin Schistosoma mansoni Z-Tyr-Pro + 7-amino-4-carbamoylmethylcoumarin
-
 ?
3.4.21.26 Z-Val-Pro-7-amido-4-carbamoylmethylcoumarin + H2O about 20% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin Homo sapiens Z-Val-Pro + 7-amino-4-carbamoylmethylcoumarin
-
 ?
3.4.21.26 Z-Val-Pro-7-amido-4-carbamoylmethylcoumarin + H2O about 38% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin Schistosoma mansoni Z-Val-Pro + 7-amino-4-carbamoylmethylcoumarin
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.21.26 ? x * 80000, SDS-PAGE Schistosoma mansoni
3.4.21.26 ? x * 82000, calculated from amino acid sequence Schistosoma mansoni

Synonyms

EC Number Synonyms Comment Organism
3.4.21.26 POP
-
 Homo sapiens
3.4.21.26 POP
-
 Schistosoma mansoni

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.21.26 8
-
-
 Schistosoma mansoni

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.4.21.26 6 10 about 30% activity at pH 6.0, about 70% activity at pH 7.0, 100% activity at pH 8.0, about 60% activity at pH 9.0, about 40% activity at pH 10.0, no enzyme activity below pH 5.0 Schistosoma mansoni

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.21.26 0.0000029
-
 at pH 8.0 and 37°C Schistosoma mansoni Z-Arg-Pro-chloromethylketone
3.4.21.26 0.0000032
-
 at pH 8.0 and 37°C Schistosoma mansoni Z-Ala-Pro-chloromethylketone
3.4.21.26 0.0000048
-
 at pH 8.0 and 37°C Homo sapiens Z-Arg-Pro-chloromethylketone
3.4.21.26 0.000012
-
 at pH 8.0 and 37°C Homo sapiens Z-Pro-Pro-aldehyde
3.4.21.26 0.0000168
-
 at pH 8.0 and 37°C Homo sapiens Z-Ala-Pro-chloromethylketone
3.4.21.26 0.000083
-
 at pH 8.0 and 37°C Homo sapiens SUAM 14746
3.4.21.26 0.000092
-
 at pH 8.0 and 37°C Schistosoma mansoni SUAM 14746
3.4.21.26 0.00016
-
 at pH 8.0 and 37°C Schistosoma mansoni Z-Pro-Pro-aldehyde
3.4.21.26 0.00049
-
 at pH 8.0 and 37°C Homo sapiens Y-29794 oxalate
3.4.21.26 0.0013
-
 at pH 8.0 and 37°C Schistosoma mansoni Z-Arg-Pro-aldehyde
3.4.21.26 0.0024
-
 at pH 8.0 and 37°C Homo sapiens Z-Arg-Pro-aldehyde
3.4.21.26 0.003
-
 at pH 8.0 and 37°C Schistosoma mansoni Z-Lys-Pro-aldehyde
3.4.21.26 0.0031
-
 at pH 8.0 and 37°C Schistosoma mansoni Z-Ala-Pro-aldehyde
3.4.21.26 0.0044
-
 at pH 8.0 and 37°C Schistosoma mansoni Z-Tyr-Pro-aldehyde
3.4.21.26 0.0061
-
 at pH 8.0 and 37°C Homo sapiens Z-Ala-Pro-aldehyde
3.4.21.26 0.0061
-
 at pH 8.0 and 37°C Schistosoma mansoni Z-Gly-Pro-aldehyde
3.4.21.26 0.0072
-
 at pH 8.0 and 37°C Homo sapiens Z-Lys-Pro-aldehyde
3.4.21.26 0.0076
-
 at pH 8.0 and 37°C Homo sapiens Z-Gly-Pro-aldehyde
3.4.21.26 0.0086
-
 at pH 8.0 and 37°C Schistosoma mansoni Y-29794 oxalate
3.4.21.26 0.011
-
 at pH 8.0 and 37°C Homo sapiens Z-Tyr-Pro-aldehyde