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Literature summary extracted from

  • Riahi, H.; Brekelmans, C.; Foriel, S.; Merkling, S.H.; Lyons, T.A.; Itskov, P.M.; Kleefstra, T.; Ribeiro, C.; van Rij, R.P.; Kramer, J.M.; Schenck, A.
    The histone methyltransferase G9a regulates tolerance to oxidative stress-induced energy consumption (2019), PLoS Biol., 17, e2006146 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.355 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 Drosophila melanogaster overall reaction 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
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Organism

EC Number Organism UniProt Comment Textmining
2.1.1.355 Drosophila melanogaster
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-
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.355 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 overall reaction Drosophila melanogaster 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
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?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.355 G9a
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Drosophila melanogaster
2.1.1.355 H3K9 methyltransferase
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Drosophila melanogaster

General Information

EC Number General Information Comment Organism
2.1.1.355 malfunction during oxidative stress exposure, enzyme mutants show overactivation of stress response genes, rapid depletion of glycogen, and inability to access lipid energy stores Drosophila melanogaster
2.1.1.355 physiological function the enzyme acts as a critical regulatory hub between the transcriptional and metabolic responses to oxidative stress Drosophila melanogaster