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Literature summary extracted from

  • Busch, B.; Hertweck, C.
    Evolution of metabolic diversity in polyketide-derived pyrones Using the non-colinear aureothin assembly line as a model system (2009), Phytochemistry, 70, 1833-1840 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.289 expression of subunit AurA in Streptomyces lividans Streptomyces thioluteus

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.289 additional information construction of mutant protein complexes each lacking a critical PKS domain on subunit AurA domain for chain propagation Streptomyces thioluteus

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.289 Streptomyces thioluteus Q70KH8 and Q70KH5 and Q70KH4 Q70KH8 i.e. subunit AurA, Q70KH5 i.e. subunit AurB, Q70KH4 i.e. subunit AurC
-
2.3.1.289 Streptomyces thioluteus HKI-227 Q70KH8 and Q70KH5 and Q70KH4 Q70KH8 i.e. subunit AurA, Q70KH5 i.e. subunit AurB, Q70KH4 i.e. subunit AurC
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.289 4-nitrobenzoyl-CoA + malonyl-CoA + 4 (S)-methylmalonyl-CoA + 4 NADPH + 4 H+
-
 Streptomyces thioluteus demethylluteothin + 5 CO2 + 6 CoA + 4 NADP+ + 3 H2O
-
 ?
2.3.1.289 4-nitrobenzoyl-CoA + malonyl-CoA + 4 (S)-methylmalonyl-CoA + 4 NADPH + 4 H+
-
 Streptomyces thioluteus HKI-227 demethylluteothin + 5 CO2 + 6 CoA + 4 NADP+ + 3 H2O
-
 ?

General Information

EC Number General Information Comment Organism
2.3.1.289 physiological function model of the itinerative action of polyketide synthase. The ACP-bound polyketide intermediate is transferred back to the ketosynthase domain on the opposite polyketide synthase strand. the AurA N-terminus is not involved in the iteration process Streptomyces thioluteus