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Literature summary extracted from

  • Sagheddu, C.; Scherma, M.; Congiu, M.; Fadda, P.; Carta, G.; Banni, S.; Wood, J.T.; Makriyannis, A.; Malamas, M.S.; Pistis, M.
    Inhibition of N-acylethanolamine acid amidase reduces nicotine-induced dopamine activation and reward (2019), Neuropharmacology, 144, 327-336 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.60 3,5-dichloro-4-nitropyridine AM11095, synthetis of the specific brain permeable NAAA inhibitor, a slowly reversible NAAA inhibitor Homo sapiens
3.5.1.60 3,5-dichloro-4-nitropyridine AM11095, synthetis is of the specific brain permeable NAAA inhibitor, a slowly reversible NAAA inhibitor Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.5.1.60 lysosome
-
 Homo sapiens 5764
-
3.5.1.60 lysosome
-
 Rattus norvegicus 5764
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.60 N-oleoylethanolamide + H2O Homo sapiens
-
 oleate + ethanolamine
-
 ?
3.5.1.60 N-oleoylethanolamide + H2O Rattus norvegicus
-
 oleate + ethanolamine
-
 ?
3.5.1.60 N-oleoylethanolamide + H2O Rattus norvegicus Sprague-Dawley
-
 oleate + ethanolamine
-
 ?
3.5.1.60 N-palmitoylethanolamide + H2O Homo sapiens
-
 palmitate + ethanolamine
-
 ?
3.5.1.60 N-palmitoylethanolamide + H2O Rattus norvegicus
-
 palmitate + ethanolamine
-
 ?
3.5.1.60 N-palmitoylethanolamide + H2O Rattus norvegicus Sprague-Dawley
-
 palmitate + ethanolamine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.60 Homo sapiens Q02083
-
-
3.5.1.60 Rattus norvegicus Q6P7S1
-
-
3.5.1.60 Rattus norvegicus Sprague-Dawley Q6P7S1
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.60 brain
-
 Homo sapiens
-
3.5.1.60 brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.60 N-oleoylethanolamide + H2O
-
 Homo sapiens oleate + ethanolamine
-
 ?
3.5.1.60 N-oleoylethanolamide + H2O
-
 Rattus norvegicus oleate + ethanolamine
-
 ?
3.5.1.60 N-oleoylethanolamide + H2O
-
 Rattus norvegicus Sprague-Dawley oleate + ethanolamine
-
 ?
3.5.1.60 N-palmitoylethanolamide + H2O
-
 Homo sapiens palmitate + ethanolamine
-
 ?
3.5.1.60 N-palmitoylethanolamide + H2O
-
 Rattus norvegicus palmitate + ethanolamine
-
 ?
3.5.1.60 N-palmitoylethanolamide + H2O
-
 Rattus norvegicus Sprague-Dawley palmitate + ethanolamine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.1.60 N-acylethanolamine acid amidase
-
 Homo sapiens
3.5.1.60 N-acylethanolamine acid amidase
-
 Rattus norvegicus
3.5.1.60 NAAA
-
 Homo sapiens
3.5.1.60 NAAA
-
 Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.5.1.60 0.00002
-
 pH and temperature not specified in the publication Homo sapiens 3,5-dichloro-4-nitropyridine

General Information

EC Number General Information Comment Organism
3.5.1.60 malfunction effects of pretreatment with the NAAA inhibitor AM11095 on nicotine-related effects in the rat mesolimbic dopamine system, phenotype, detailed overview Rattus norvegicus