Literature summary extracted from

Han, S.; Schroeder, E.A.; Silva-Garcia, C.G.; Hebestreit, K.; Mair, W.B.; Brunet, A.
Mono-unsaturated fatty acids link H3K4me3 modifiers to C. elegans lifespan (2017), Nature, 544, 185-190 .

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2.1.1.354	3 S-adenosyl-L-methionine + a [histone H3]-L-lysine4	Caenorhabditis elegans	overall reaction	3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.1.1.354	Caenorhabditis elegans	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.1.1.354	3 S-adenosyl-L-methionine + a [histone H3]-L-lysine4	overall reaction	Caenorhabditis elegans	3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
2.1.1.354	COMPASS chromatin complex	-	Caenorhabditis elegans
2.1.1.354	H3K4me3 methyltransferase	-	Caenorhabditis elegans

General Information

EC Number	General Information	Comment	Organism
2.1.1.354	malfunction	an enzyme deficiency promotes fat accumulation in worms with a specific enrichment of mono-unsaturated fatty acids	Caenorhabditis elegans
2.1.1.354	physiological function	the enzyme regulates lifespan in Caenorhabditis elegans	Caenorhabditis elegans

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Release 2023.1 (January 2023)