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Literature summary extracted from

  • Agger, K.; Cloos, P.A.; Christensen, J.; Pasini, D.; Rose, S.; Rappsilber, J.; Issaeva, I.; Canaani, E.; Salcini, A.E.; Helin, K.
    UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development (2007), Nature, 449, 731-734 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.11.68 [histone H3]-N6,N6,N6-trimethyllysine27 + 2 2-oxoglutarate + 2 O2 Homo sapiens
-
 [histone H3]-N6-methyllysine27 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?
1.14.11.68 [histone H3]-N6,N6,N6-trimethyllysine27 + 2-oxoglutarate + O2 Homo sapiens
-
 [histone H3]-N6,N6-dimethyllysine27 + succinate + formaldehyde + CO2
-
 ?
1.14.11.68 [histone H3]-N6,N6-dimethyllysine27 + 2-oxoglutarate + O2 Homo sapiens
-
 [histone H3]-N6-methyllysine27 + succinate + formaldehyde + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.68 Caenorhabditis elegans Q95QK3
-
-
1.14.11.68 Homo sapiens O15054
-
-
1.14.11.68 Homo sapiens O15550
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.68 a [histone H3]-N6,N6,N6-trimethyl-L-lysine27 + 2 2-oxoglutarate + 2 O2
-
 Homo sapiens a [histone H3]-N6-methyl-L-lysine27 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?
1.14.11.68 a [histone H3]-N6,N6,N6-trimethyl-L-lysine27 + 2-oxoglutarate + O2
-
 Homo sapiens a [histone H3]-N6,N6-dimethyl-L-lysine27 + succinate + formaldehyde + CO2
-
 ?
1.14.11.68 a [histone H3]-N6,N6-dimethyl-L-lysine27 + 2-oxoglutarate + O2
-
 Homo sapiens a [histone H3]-N6-methyl-L-lysine27 + succinate + formaldehyde + CO2
-
 ?
1.14.11.68 [histone H3]-N6,N6,N6-trimethyllysine27 + 2 2-oxoglutarate + 2 O2
-
 Homo sapiens [histone H3]-N6-methyllysine27 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?
1.14.11.68 [histone H3]-N6,N6,N6-trimethyllysine27 + 2-oxoglutarate + O2
-
 Homo sapiens [histone H3]-N6,N6-dimethyllysine27 + succinate + formaldehyde + CO2
-
 ?
1.14.11.68 [histone H3]-N6,N6-dimethyllysine27 + 2-oxoglutarate + O2
-
 Homo sapiens [histone H3]-N6-methyllysine27 + succinate + formaldehyde + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.11.68 F18E9.5
-
 Caenorhabditis elegans
1.14.11.68 jmjd-3.1
-
 Caenorhabditis elegans
1.14.11.68 JMJD3
-
 Homo sapiens
1.14.11.68 KDM6A
-
 Homo sapiens
1.14.11.68 KDM6B
-
 Homo sapiens
1.14.11.68 lysine-specific demethylase 6A
-
 Homo sapiens
1.14.11.68 lysine-specific demethylase 6B
-
 Homo sapiens
1.14.11.68 UTX
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.14.11.68 physiological function JmjC-domain-containing proteins UTX and JMJD3 demethylate tri-methylated Lys 27 on histone H3. Ectopic expression of JMJD3 leads to a strong decrease of H3K27me3 levels and causes delocalization of polycomb proteins in vivo. H3K27me3 demethylation regulated by UTX/JMJD3 proteins is essential for proper development Homo sapiens
1.14.11.68 physiological function JmjC-domain-containing proteins UTX and JMJD3 demethylate tri-methylated Lys 27 on histone H3. H3K27me3 demethylation regulated by UTX/JMJD3 proteins is essential for proper development Homo sapiens
1.14.11.68 physiological function mutation of JMJD3 orthologue, or inhibition of its expression, results in abnormal gonad development Caenorhabditis elegans