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Literature summary extracted from

  • Mueller, M.M.; Fierz, B.; Bittova, L.; Liszczak, G.; Muir, T.W.
    A two-state activation mechanism controls the histone methyltransferase Suv39h1 (2016), Nat. Chem. Biol., 12, 188-193 .
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.1.1.355 additional information the addition of an [histone H3]-N6,N6,N6-trimethyl-L-lysine9-containing peptide strongly enhances enzyme activity on unmodified chromatin Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.355 expressed in Sf9 insect cells Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.1.1.355 Mg2+ 5 mM used in assay conditions Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.355 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 Homo sapiens overall reaction 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
?
2.1.1.355 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 Homo sapiens
-
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9
-
?
2.1.1.355 S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9 Homo sapiens
-
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
?
2.1.1.355 S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9 Homo sapiens
-
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.355 Homo sapiens O43463
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.355 anti-FLAG M2 affinity column chromatography Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.355 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 overall reaction Homo sapiens 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
?
2.1.1.355 S-adenosyl-L-methionine + a [histone H3]-L-lysine9
-
Homo sapiens S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9
-
?
2.1.1.355 S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9
-
Homo sapiens S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
?
2.1.1.355 S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9
-
Homo sapiens S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9
-
?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.355 KMT1A
-
Homo sapiens
2.1.1.355 SUV39H1
-
Homo sapiens