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Literature summary extracted from

  • Gao, L.Y.; Laval, F.; Lawson, E.H.; Groger, R.K.; Woodruff, A.; Morisaki, J.H.; Cox, J.S.; Daffe, M.; Brown, E.J.
    Requirement for kasB in Mycobacterium mycolic acid biosynthesis, cell wall impermeability and intracellular survival implications for therapy (2003), Mol. Microbiol., 49, 1547-1563 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.294 expressed in Mycobacterium marinum kasB mutants Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.294 an ultra-long-chain di-unsaturated acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] Mycobacterium tuberculosis
-
 an ultra-long-chain di-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]
-
 ?
2.3.1.294 an ultra-long-chain di-unsaturated acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] Mycobacterium tuberculosis H37Rv
-
 an ultra-long-chain di-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.294 Mycobacterium tuberculosis
-
-
-
2.3.1.294 Mycobacterium tuberculosis H37Rv
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.294 an ultra-long-chain di-unsaturated acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein]
-
 Mycobacterium tuberculosis an ultra-long-chain di-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]
-
 ?
2.3.1.294 an ultra-long-chain di-unsaturated acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein]
-
 Mycobacterium tuberculosis H37Rv an ultra-long-chain di-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.294 beta-ketoacyl-acyl carrier protein synthase B
-
 Mycobacterium tuberculosis
2.3.1.294 KasB
-
 Mycobacterium tuberculosis

General Information

EC Number General Information Comment Organism
2.3.1.294 malfunction enzyme mutants exhibit strikingly altered cell wall permeability, leading to a marked increase in susceptibility to lipophilic antibiotics and the host antimicrobial molecules defensing and lysozyme. The predominant chain lengths are 2-4 carbons shorter for oxygenated mycolates in the absence of the enzyme Mycobacterium tuberculosis
2.3.1.294 physiological function enzyme-dependent mycolate elongation is essential for cording and cell wall impermeability. Enzyme-dependent cell wall impermeability is essential for antibiotic resistance. The enzyme is essential for resistance to macrophage antimicrobial activity Mycobacterium tuberculosis