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Literature summary extracted from

  • Boros, J.; Arnoult, N.; Stroobant, V.; Collet, J.F.; Decottignies, A.
    Polycomb repressive complex 2 and H3K27me3 cooperate with H3K9 methylation to maintain heterochromatin protein 1alpha at chromatin (2014), Mol. Cell. Biol., 34, 3662-3674 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.356 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine27 Mus musculus overall reaction 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine27
-
 ?
2.1.1.356 S-adenosyl-L-methionine + a [histone H3]-L-lysine27 Mus musculus
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine27
-
 ?
2.1.1.356 S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine27 Mus musculus
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine27
-
 ?
2.1.1.356 S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine27 Mus musculus
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine27
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.356 Mus musculus Q61188
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.356 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine27 overall reaction Mus musculus 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine27
-
 ?
2.1.1.356 S-adenosyl-L-methionine + a [histone H3]-L-lysine27
-
 Mus musculus S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine27
-
 ?
2.1.1.356 S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine27
-
 Mus musculus S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine27
-
 ?
2.1.1.356 S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine27
-
 Mus musculus S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine27
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.356 EZH2 catalytic subunit Mus musculus
2.1.1.356 Polycomb repressive complex 2
-
 Mus musculus
2.1.1.356 PRC2
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.1.1.356 malfunction enzyme depletion leads to heterochromatin protein 1alpha loss from chromatin and degradation Mus musculus
2.1.1.356 physiological function the enzyme and H3K27me3 cooperate with [histone H3]-L-lysine27 methylation to maintain heterochromatin protein 1alpha at chromatin Mus musculus