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Literature summary extracted from

  • Merrill, A.H.; Wang, E.
    Enzymes of ceramide biosynthesis (1992), Methods Enzymol., 209, 427-437 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.24 fumonisin B1 potent inhibition Bos taurus
2.3.1.24 fumonisin B1 potent inhibition Rattus norvegicus
2.3.1.24 Fumonisin B2 potent inhibition Bos taurus
2.3.1.24 Fumonisin B2 potent inhibition Rattus norvegicus
2.3.1.24 additional information fumonisins are mycotoxins from Fusarium moniliforme Bos taurus
2.3.1.24 additional information fumonisins are mycotoxins from Fusarium moniliforme Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.24 microsome
-
 Rattus norvegicus
-
-
2.3.1.24 microsome
-
 Bos taurus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.24 sphinganine + palmitoyl-CoA Rattus norvegicus
-
 N-palmitoylsphinganine + CoA
-
 ?
2.3.1.24 sphinganine + palmitoyl-CoA Bos taurus
-
 N-palmitoylsphinganine + CoA
-
 ?
2.3.1.24 sphinganine + stearoyl-CoA Rattus norvegicus
-
 N-stearoylsphinganine + CoA
-
 ?
2.3.1.24 sphinganine + stearoyl-CoA Bos taurus
-
 N-stearoylsphinganine + CoA
-
 ?
2.3.1.24 sphingosine + palmitoyl-CoA Rattus norvegicus
-
 N-palmitoylsphingosine + CoA
-
 ?
2.3.1.24 sphingosine + palmitoyl-CoA Bos taurus
-
 N-palmitoylsphingosine + CoA
-
 ?
2.3.1.24 sphingosine + stearoyl-CoA Rattus norvegicus
-
 N-stearoylsphingosine + CoA
-
 ?
2.3.1.24 sphingosine + stearoyl-CoA Bos taurus
-
 N-stearoylsphingosine + CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.24 Bos taurus
-
-
-
2.3.1.24 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.24 brain
-
 Bos taurus
-
2.3.1.24 hepatocyte
-
 Rattus norvegicus
-
2.3.1.24 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.24 additional information the enzyme is also active with longer-chain acyl-CoAs. Substrate preparation, overview. Usage of radiolabeled, or fluorescent substrates Rattus norvegicus ?
-
 ?
2.3.1.24 additional information the enzyme is also active with longer-chain acyl-CoAs. Substrate preparation, overview. Usage of radiolabeled, or fluorescent substrates Bos taurus ?
-
 ?
2.3.1.24 sphinganine + palmitoyl-CoA
-
 Rattus norvegicus N-palmitoylsphinganine + CoA
-
 ?
2.3.1.24 sphinganine + palmitoyl-CoA
-
 Bos taurus N-palmitoylsphinganine + CoA
-
 ?
2.3.1.24 sphinganine + stearoyl-CoA
-
 Rattus norvegicus N-stearoylsphinganine + CoA
-
 ?
2.3.1.24 sphinganine + stearoyl-CoA
-
 Bos taurus N-stearoylsphinganine + CoA
-
 ?
2.3.1.24 sphingosine + palmitoyl-CoA
-
 Rattus norvegicus N-palmitoylsphingosine + CoA
-
 ?
2.3.1.24 sphingosine + palmitoyl-CoA
-
 Bos taurus N-palmitoylsphingosine + CoA
-
 ?
2.3.1.24 sphingosine + stearoyl-CoA
-
 Rattus norvegicus N-stearoylsphingosine + CoA
-
 ?
2.3.1.24 sphingosine + stearoyl-CoA
-
 Bos taurus N-stearoylsphingosine + CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.24 (dihydro)ceramide synthase
-
 Rattus norvegicus
2.3.1.24 (dihydro)ceramide synthase
-
 Bos taurus
2.3.1.24 acyl-CoA : sphingosine N-acyltransferase
-
 Rattus norvegicus
2.3.1.24 acyl-CoA : sphingosine N-acyltransferase
-
 Bos taurus
2.3.1.24 sphingosine/sphinganine acyltransferase
-
 Rattus norvegicus
2.3.1.24 sphingosine/sphinganine acyltransferase
-
 Bos taurus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.24 37
-
 assay at Rattus norvegicus
2.3.1.24 37
-
 assay at Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.24 7.4
-
 assay at Rattus norvegicus
2.3.1.24 7.4
-
 assay at Bos taurus

General Information

EC Number General Information Comment Organism
2.3.1.24 metabolism the enzyme catalyzes a step in the ceramide biosynthesis, the CoA-dependent addition of a long-chain fatty acid to sphinganine. Sphinganine might be converted to sphingosine first. Pathway regulation, overview Rattus norvegicus
2.3.1.24 metabolism the enzyme catalyzes a step in the ceramide biosynthesis, the CoA-dependent addition of a long-chain fatty acid to sphinganine. Sphinganine might be converted to sphingosine first. Pathway regulation, overview Bos taurus