Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Li, J.; Li, R.; Li, N.; Zheng, F.; Dai, Y.; Ge, Y.; Yue, H.; Yu, S.
    Mechanism of antidiabetic and synergistic effects of ginseng polysaccharide and ginsenoside Rb1 on diabetic rat model (2018), J. Pharm. Biomed. Anal., 158, 451-460 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.191 Ginseng polysaccharides GP, when a high dose of GP is fed to diabetic rats for 15 days, the formation of intermediates, including gypenoside XVII and gypenoside LXXV is inhibited, and only one pathway (Rb1-> Rd -> F2 -> CK) is identified uncultured bacterium

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.1.191 additional information uncultured bacterium during transformation of Rb1 by diabetic rat intestinal microflora, five transformed products, including ginsenoside Rd, F2, CK, gypenoside XVII (G-XVII), and LXXV (G-LXXV), as well as three transformation pathways, are identified ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.191 uncultured bacterium
-
 from diabetic rat intestinal microflora via fresh feces
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.191 4-nitrophenyl-beta-D-glucopyranoside + H2O
-
 uncultured bacterium 4-nitrophenol + D-glucopyranose
-
 ?
3.2.1.191 ginsenoside F2 + H2O
-
 uncultured bacterium ginsenoside C-K + D-glucopyranose
-
 ?
3.2.1.191 ginsenoside Rb1 + H2O cf. EC 3.2.1.192 or EC 3.2.1.195 uncultured bacterium ginsenoside Rd + D-glucopyranose
-
 ?
3.2.1.191 ginsenoside Rb1 + H2O
-
 uncultured bacterium gypenoside XVII + D-glucopyranose
-
 ?
3.2.1.191 ginsenoside Rd + H2O
-
 uncultured bacterium ginsenoside F2 + D-glucopyranose
-
 ?
3.2.1.191 gypenoside LXXV + H2O G-LXXV uncultured bacterium ginsenoside C-K + D-glucopyranose
-
 ?
3.2.1.191 gypenoside XVII + H2O G-XVII uncultured bacterium gypenoside LXXV + D-glucose
-
 ?
3.2.1.191 gypenoside XVII + H2O cf. EC 3.2.1.193 uncultured bacterium ginsenoside F2 + D-glucopyranose
-
 ?
3.2.1.191 additional information during transformation of Rb1 by diabetic rat intestinal microflora, five transformed products, including ginsenoside Rd, F2, CK, gypenoside XVII (G-XVII), and LXXV (G-LXXV), as well as three transformation pathways, are identified uncultured bacterium ?
-
 ?
3.2.1.191 additional information when a high dose of Ginseng polysaccharides is fed to diabetic rats for 15 days, the formation of intermediates, including gypenoside XVII and gypenoside LXXV is inhibited, and only one pathway (Rb1-> Rd -> F2 -> CK) is identified, cf. EC 3.2.1.192 or EC 3.2.1.195. Mass spectrometric identification of substrates and products, overview uncultured bacterium ?
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.2.1.191 37
-
 assay at uncultured bacterium

General Information

EC Number General Information Comment Organism
3.2.1.191 metabolism pathways of ginsenoside Rb1 biotransformation in diabetic rat intestinal microflora, overview. The first is Rb1 -> Rd -> F2 -> CK. The second pathway is Rb1 -> G-XVII -> G-LXXV -> CK. The third pathway is Rb1 -> G-XVII -> F2 -> CK. Ginseng polysaccharides restore the dysbiosis of intestinal flora in diabetic rats uncultured bacterium