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Literature summary extracted from

  • Sanson, B.; Hu, R.M.; Troitskayadagger, E.; Mathy, N.; Uzan, M.
    Endoribonuclease RegB from bacteriophage T4 is necessary for the degradation of early but not middle or late mRNAs (2000), J. Mol. Biol., 297, 1063-1074 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.6.1.25 a [pre-mRNA]-containing guanosine-adenosine + H2O Tequatrovirus T4 the enzyme is necessary for the degradation of early but not middle or late mRNAs. The synthesis of several early proteins is down-regulated, probably as a consequence of RegB cleavages in the Shine-Dalgarno sequence of these genes. The synthesis of several other proteins is up-regulated, suggesting that processing by RegB might improve translation by changing the conformation of a transcript a 5'-hydroxy-guanosine-[premRNA fragment] + a [pre-mRNA fragment]-3'-adenosine-3'-phosphate
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Organism

EC Number Organism UniProt Comment Textmining
4.6.1.25 Tequatrovirus T4 P13312
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Purification (Commentary)

EC Number Purification (Comment) Organism
4.6.1.25
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 Tequatrovirus T4

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.25 a [pre-mRNA]-containing guanosine-adenosine + H2O the enzyme is necessary for the degradation of early but not middle or late mRNAs. The synthesis of several early proteins is down-regulated, probably as a consequence of RegB cleavages in the Shine-Dalgarno sequence of these genes. The synthesis of several other proteins is up-regulated, suggesting that processing by RegB might improve translation by changing the conformation of a transcript Tequatrovirus T4 a 5'-hydroxy-guanosine-[premRNA fragment] + a [pre-mRNA fragment]-3'-adenosine-3'-phosphate
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 ?
4.6.1.25 a [pre-mRNA]-containing guanosine-adenosine + H2O the enzyme cleaves early mRNAs between Ap and Gp at one specific specific GpGpApGp site. Many intergenic GGAG motifs, including Shine-Dalgarno sequences, are not substrates for RegB Tequatrovirus T4 a 5'-hydroxy-guanosine-[premRNA fragment] + a [pre-mRNA fragment]-3'-adenosine-3'-phosphate
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Synonyms

EC Number Synonyms Comment Organism
4.6.1.25 endoribonuclease RegB
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 Tequatrovirus T4

General Information

EC Number General Information Comment Organism
4.6.1.25 physiological function the enzyme is necessary for the degradation of early but not middle or late mRNAs. The synthesis of several early proteins is down-regulated, probably as a consequence of RegB cleavages in the Shine-Dalgarno sequence of these genes. TRegB also regulates the translation of several prereplicative genes Tequatrovirus T4